Pdgfb - platelet derived growth factor, B polypeptide Gene

Mus musculus

Also known as Sis; c-sis; PDGF-2; PDGF-B

Gene ID: 18591 | Gene type: protein coding

About Pdgfb

Summary

Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including metanephric glomerular mesangium development; paracrine signaling; and positive regulation of glomerular filtration. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of cell migration. Predicted to be located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue Cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfb Products(3)

mRNA	Protein	Name
NM_001411619.1	NP_001398548.1	platelet-derived growth factor subunit B isoform 2
NM_001411620.1	NP_001398549.1	platelet-derived growth factor subunit B isoform 2
NM_011057.5	NP_035187.2	platelet-derived growth factor subunit B isoform 1 preproprotein

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IDA IDA: Inferred from direct assay	12176888	MGI
acts upstream of or within actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	16456542	MGI
involved in blood vessel development	IEP IEP: Inferred from expression pattern	10375497	MGI
acts upstream of or within blood vessel morphogenesis	IDA IDA: Inferred from direct assay	15919073	MGI
acts upstream of or within blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	15919073	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	18559345	MGI
acts upstream of cell migration	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of or within cell projection assembly	IDA IDA: Inferred from direct assay	12176888	MGI
involved in cellular response to platelet-derived growth factor stimulus	IDA IDA: Inferred from direct assay	28867608	MGI
involved in embryonic placenta development	IMP IMP: Inferred from mutant phenotype	15084468	MGI
acts upstream of endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	18559345	MGI
acts upstream of or within eye photoreceptor cell development	IMP IMP: Inferred from mutant phenotype	25224828	MGI
acts upstream of fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	18559345	MGI
acts upstream of or within fibroblast migration	IDA IDA: Inferred from direct assay	15183724	MGI
acts upstream of fibroblast migration	IGI IGI: Inferred from genetic interaction	16456542	MGI
acts upstream of or within glial cell development	IMP IMP: Inferred from mutant phenotype	25224828	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	15084468	MGI
involved in metanephric glomerular endothelium development	IEP IEP: Inferred from expression pattern	9693135	MGI
involved in metanephric glomerular mesangial cell development	IMP IMP: Inferred from mutant phenotype	15084468	MGI
involved in metanephric glomerular mesangial cell proliferation involved in metanephros development	IMP IMP: Inferred from mutant phenotype	9693135	MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell migration	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of or within neuron remodeling	IMP IMP: Inferred from mutant phenotype	25224828	MGI
involved in paracrine signaling	IMP IMP: Inferred from mutant phenotype	15084468	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	16456542	MGI
acts upstream of or within positive regulation of endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of or within positive regulation of fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	18559345	MGI
acts upstream of or within positive regulation of fibroblast migration	IGI IGI: Inferred from genetic interaction	16456542	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	28867608	MGI
involved in positive regulation of glomerular filtration	IMP IMP: Inferred from mutant phenotype	15084468	MGI
acts upstream of or within positive regulation of mitotic cell cycle, embryonic	IGI IGI: Inferred from genetic interaction	18827006	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	16456542	MGI
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	10375497	MGI
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	28867608	MGI
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	10375497	MGI
acts upstream of or within positive regulation of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11940581	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	25224828	MGI
acts upstream of or within retina vasculature development in camera-type eye	IMP IMP: Inferred from mutant phenotype	25224828	MGI
acts upstream of or within substrate-dependent cell migration	IDA IDA: Inferred from direct assay	15183724	MGI
acts upstream of or within synapse assembly	IMP IMP: Inferred from mutant phenotype	25224828	MGI
acts upstream of vascular associated smooth muscle cell migration	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	16644864	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

platelet-derived growth factor subunit B

PDGF subunit B	platelet-derived growth factor B chain
platelet-derived growth factor beta polypeptide	proto-oncogene c-Sis

Recombinant Pdgfb Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7087	PDGF-BB Protein, Mouse	P31240 (S82-T190)	≥95%
HY-P70699	PDGF-BB Protein, Mouse (His)	AAH53430.1 (S82-T190)	≥95%
HY-P73352	PDGF-BB Protein, Mouse (P.pastoris, His)	AAH23427.1 (S82-T190)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160047	AX102 sodium		/	Unkown
HY-160048	PEG40K unconjugated/naked AX102 sodium		/	Unkown
HY-RS10251	PDGFB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdgfb	NCBI	NCBI:5155
Canis familiaris	Pdgfb	NCBI	NCBI:442986
Macaca fascicularis	Pdgfb	NCBI	NCBI:102125183
Rattus norvegicus	Pdgfb	NCBI	NCBI:24628
Macaca mulatta	Pdgfb	NCBI	NCBI:703173

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