Pdgfb - platelet derived growth factor, B polypeptide Gene

Also known as Sis; c-sis; PDGF-2; PDGF-B

About Pdgfb

Summary

Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including metanephric glomerular mesangium development; paracrine signaling; and positive regulation of glomerular filtration. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of cell migration. Predicted to be located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue Cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Apr 2022]