Ptpn1 - protein tyrosine phosphatase, non-receptor type 1 Gene

Rattus norvegicus

Also known as Ptp

Gene ID: 24697 | Gene type: protein coding

About Ptpn1

Summary

Enables Insulin Receptor binding activity; protein Phosphatase 2A binding activity; and protein tyrosine Phosphatase activity. Involved in protein dephosphorylation and regulation of Insulin Receptor signaling pathway. Located in cytoplasmic vesicle; cytosol; and mitochondrion. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine Phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn1 Products(1)

mRNA	Protein	Name
NM_012637.2	NP_036769.1	tyrosine-protein phosphatase non-receptor type 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables insulin receptor binding	IDA IDA: Inferred from direct assay	7711057	RGD
enables insulin receptor binding	IMP IMP: Inferred from mutant phenotype	12850498	RGD
enables phosphatase activity	IDA IDA: Inferred from direct assay	10409197	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7685104	RGD
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	17897622	RGD
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	7711057	RGD
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	17563729	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	18278556	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	31502193	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	15271661	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	18278556	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	18456732	RGD
involved in cellular response to nerve growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18796006	RGD
involved in cellular response to nitric oxide	IMP IMP: Inferred from mutant phenotype	12117721	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	15271661	RGD
involved in dephosphorylation	IDA IDA: Inferred from direct assay	10409197	RGD
involved in dephosphorylation	IMP IMP: Inferred from mutant phenotype	10409197	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16373608	RGD
involved in negative regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	10484424	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	18796006	RGD
involved in negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	12117721	RGD
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	31502193	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18278556	RGD
involved in negative regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	10409197	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	18278556	RGD
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	31502193	RGD
involved in positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	22569287	RGD
involved in positive regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	22569287	RGD
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	7711057	RGD
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	17563729	RGD
involved in regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12941932	RGD
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	22844492	RGD
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	22844492	RGD
involved in regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	18278556	RGD
involved in response to angiotensin	IEP IEP: Inferred from expression pattern	22526299	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	21788123	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22844492	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22844492	RGD
located in mitochondrial crista	IDA IDA: Inferred from direct assay	18583343	RGD
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	18583343	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	22844492	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 1

PTP-1B

protein-tyrosine phosphatase 1B

Ptpn1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ptpn1	P20417	EGFR	Homo sapiens	P00533	Phosphatase Assay	8621392
Cross	Ptpn1	P20417	EGFR	Homo sapiens	P00533	Photoaffinity Labelling	8621392
Cross	Ptpn1	P20417	EGFR	Homo sapiens	P00533	Pull Down	7693694
Cross	Ptpn1	P20417	EGFR	Homo sapiens	P00533	Phosphatase Assay	7685104
Cross	Ptpn1	P20417	EGFR	Homo sapiens	P00533	Competition Binding	7693694

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145923	Osunprotafib	Inhibitor	99.43%	Unkown
HY-153446	Tegeprotafib	Inhibitor	99.30%	Unkown
HY-156606	Anticancer agent 142	Inhibitor	/	Unkown
HY-RS11415	PTPN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptpn1	NCBI	NCBI:5770
Mus musculus	Ptpn1	NCBI	NCBI:19246

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