Rara - retinoic acid receptor, alpha Gene

Rattus norvegicus

Gene ID: 24705 | Gene type: protein coding

About Rara

Primary_assembly 10: 83,893,384-83,928,142 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 331 orthologues, 19 paralogues and is associated with 12 phenotypes. Biased expression in Lung (RPKM 12.3), Kidney (RPKM 75.) and 9 other tissues.

Summary

Enables histone deacetylase binding activity; nucleic acid binding activity; and phosphatidylinositol 3-kinase regulator activity. Involved in several processes, including animal organ development; positive regulation of intracellular signal transduction; and response to vitamin A. Located in dendrite; nucleus; and perinuclear region of cytoplasm. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human RARA (retinoic acid receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Rara Products(1)

mRNA	Protein	Name
NM_031528.2	NP_113716.2	retinoic acid receptor alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heterocyclic compound binding	IDA IDA: Inferred from direct assay	19100254	RGD
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	21383775	RGD
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	19073915	RGD
enables mRNA regulatory element binding translation repressor activity	IDA IDA: Inferred from direct assay	19073915	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in female pregnancy	IEP IEP: Inferred from expression pattern	18342837	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	18619947	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	15388488	RGD
involved in male gonad development	IDA IDA: Inferred from direct assay	14613895	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12704731	RGD
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	19073915	RGD
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	19100254	RGD
involved in prostate gland development	IEP IEP: Inferred from expression pattern	12193579	RGD
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	12186877	RGD
involved in regulation of myelination	IDA IDA: Inferred from direct assay	20648638	RGD
involved in regulation of synaptic plasticity	IDA IDA: Inferred from direct assay	18957222	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	17078027	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	12193579	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	12954654	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	18384703	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	19073915	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12193579	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rara Protein Structure

NR_DBD_RAR

NR_LBD_RAR

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

retinoic acid receptor alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101106	AR7	Antagonist	99.38%	Unkown
HY-RS11669	RARA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11670	Rara Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11671	Rara Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rara	NCBI	NCBI:5914

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