Ccl2 - C-C motif chemokine ligand 2 Gene

Rattus norvegicus

Also known as MCP-1; Scya2; Sigje

Gene ID: 24770 | Gene type: protein coding

About Ccl2

Summary

Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and leukocyte migration. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Colocalizes with C-fiber. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); lung disease (multiple); non-alcoholic fatty liver disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system Cancer (multiple); and tuberculosis (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2). [provided by Alliance of Genome Resources, Apr 2022]

Ccl2 Products(1)

mRNA	Protein	Name
NM_031530.1	NP_113718.1	C-C motif chemokine 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	11104723	RGD
enables heparin binding	IPI IPI: Inferred from physical interaction	16127145	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	19420110	RGD
involved in cellular response to ATP	IEP IEP: Inferred from expression pattern	19125410	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	14512159	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	17237237	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	14656734	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	26222724	RGD
involved in cellular response to high density lipoprotein particle stimulus	IEP IEP: Inferred from expression pattern	18483405	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	17180354	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	14512159	RGD
involved in cellular response to interleukin-6	IEP IEP: Inferred from expression pattern	8921263	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	8921263	RGD
involved in cellular response to lipoprotein particle stimulus	IEP IEP: Inferred from expression pattern	11473635	RGD
involved in cellular response to macrophage colony-stimulating factor stimulus	IEP IEP: Inferred from expression pattern	8921263	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	7589574	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	11274229	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	14512159	RGD
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	14512159	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16331110	RGD
involved in chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18584881	RGD
involved in chronic inflammatory response	IEP IEP: Inferred from expression pattern	15104336	RGD
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16174730	RGD
involved in glial cell migration	IMP IMP: Inferred from mutant phenotype	23010641	RGD
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	15978006	RGD
involved in leukocyte migration involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	8774140	RGD
involved in lymphocyte chemotaxis	IDA IDA: Inferred from direct assay	11104723	RGD
involved in macrophage chemotaxis	IDA IDA: Inferred from direct assay	16127145	RGD
involved in mammary gland involution	IEP IEP: Inferred from expression pattern	20110414	RGD
involved in maternal process involved in female pregnancy	IEP IEP: Inferred from expression pattern	8788206	RGD
involved in maternal process involved in parturition	IEP IEP: Inferred from expression pattern	18606702	RGD
involved in neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	16127145	RGD
involved in positive regulation of NMDA glutamate receptor activity	IGI IGI: Inferred from genetic interaction	27094552	RGD
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	8103296	RGD
involved in positive regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	10225970	RGD
involved in positive regulation of cellular extravasation	IDA IDA: Inferred from direct assay	10225970	RGD
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	8663511	RGD
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	14693680	RGD
involved in positive regulation of leukocyte mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	8103296	RGD
involved in positive regulation of leukocyte migration	IDA IDA: Inferred from direct assay	7943176	RGD
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	14512159	RGD
involved in positive regulation of macrophage chemotaxis	IDA IDA: Inferred from direct assay	9430491	RGD
involved in positive regulation of monocyte chemotaxis	IDA IDA: Inferred from direct assay	1387671	RGD
involved in positive regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	22222817	RGD
involved in positive regulation of synaptic transmission	IDA IDA: Inferred from direct assay	18584881	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	24826069	RGD
involved in positive regulation of wound healing	IMP IMP: Inferred from mutant phenotype	12831234	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	18797164	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	18475188	RGD
involved in response to cyclosporin A	IEP IEP: Inferred from expression pattern	15059785	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17935147	RGD
involved in response to gamma radiation	IEP IEP: Inferred from expression pattern	19084914	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	19210118	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	19278353	RGD
involved in response to isolation stress	IEP IEP: Inferred from expression pattern	33411841	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19111613	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	18606702	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	18606702	RGD
involved in response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	15855648	RGD
involved in response to vitamin B3	IEP IEP: Inferred from expression pattern	19420110	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18388116	RGD
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14505427	RGD
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14693680	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in C-fiber	IDA IDA: Inferred from direct assay	18076762	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	19059387	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16025454	RGD
located in endocytic vesicle	IDA IDA: Inferred from direct assay	12080327	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	19060786	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15978006	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	16025454	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14512159	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C-C motif chemokine 2

chemokine (C-C motif) ligand 2	immediate-early serum-responsive JE protein
immediate-early serum-responsive protein JE	monocyte chemoattractant protein 1
monocyte chemotactic protein 1	small inducible cytokine A2
small inducible gene JE

Recombinant Ccl2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7236	MCP-1/CCL2 Protein, Rat (HEK293, C-His)	P14844 (Q24-N148)	≥95%

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0673	Pirfenidone	Inhibitor	99.98%	Yes
HY-B1322A	Amodiaquine		99.98%	Unkown
HY-B1322	Amodiaquine dihydrochloride dihydrate		99.89%	Unkown
HY-B1322B	Amodiaquine dihydrochloride		99.89%	Unkown
HY-B0673R	Pirfenidone (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B0498	Bindarit	Inhibitor	99.53%	Phase 3
HY-148100A	Emapticap pegol sodium	Inhibitor	91.06%	Phase 2
HY-148100	Emapticap pegol	Inhibitor	/	Phase 2

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99188	Carlumab	Inhibitor	97.80%	Phase 2
HY-P99450	Avdoralimab	Inhibitor	95.16%	Phase 2

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120501	B022	Inhibitor	99.37%	Unkown
HY-W007376	Indole-3-carboxaldehyde		99.96%	Unkown
HY-115644	BMS-470539 dihydrochloride	Agonist	99.85%	Unkown
HY-120897	NS-3-008 hydrochloride	Inhibitor	99.65%	Unkown
HY-149202	UT-11	Inhibitor	99.62%	Unkown
HY-160552	244cis		96.70%	Unkown
HY-B0673S	Pirfenidone-d5	Inhibitor	99.48%	Unkown
HY-116247	ST247	Agonist	99.88%	Unkown
HY-W013675	2-Methoxyhydroquinone	Pre-designed Sets	/	Unkown
HY-108554	Q94 hydrochloride	Antagonist	/	Unkown
HY-121896	DSHN	Activator	/	Unkown
HY-144334	CHIKV-IN-3	Inhibitor	/	Unkown
HY-163655	Glutaminyl Cyclase Inhibitor 6	Inhibitor	/	Unkown
HY-170415	EGR-1-IN-3	Inhibitor	/	Unkown
HY-B1322AS1	Amodiaquine-d10 hydrochloride		/	Unkown
HY-N3887	Evoxine	Inhibitor	/	Unkown
HY-RS02089	CCL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W104821	Rosolic acid	Activator	/	Unkown
HY-168782	Resolvin D2 n-3 DPA	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990297	Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccl2	NCBI	NCBI:6347
Macaca fascicularis	Ccl2	NCBI	NCBI:102135739
Mus musculus	Ccl2	NCBI	NCBI:20296
Susscrofa domestica	Ccl2	NCBI
Macaca mulatta	Ccl2	NCBI	NCBI:574138

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