2. Gene
  3. Spn - sialophorin Gene

Spn - sialophorin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Lsn; Cd43; Lsn1; gpL115

Gene ID: 24796 | Gene type: protein coding

About Spn

Summary

Enables protein domain specific binding activity. Involved in several processes, including T cell receptor signaling pathway; monocyte activation; and thymocyte aggregation. Located in cell surface; cleavage furrow; and microvillus. Orthologous to human SPN (sialophorin). [provided by Alliance of Genome Resources, Apr 2022]

Spn Products(1)

mRNA Protein Name
NM_001271086.1 NP_001258015.1 leukosialin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9472040 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
18614175 RGD
Biological Process GO Annotation Evidence Reference Source
involved in T cell receptor signaling pathway IGI
IGI: Inferred from genetic interaction
12496963 RGD
involved in chronic inflammatory response IEP
IEP: Inferred from expression pattern
10486239 RGD
involved in monocyte activation IEP
IEP: Inferred from expression pattern
9400815 RGD
involved in regulation of gene expression IGI
IGI: Inferred from genetic interaction
12496963 RGD
involved in thymocyte aggregation IMP
IMP: Inferred from mutant phenotype
1382990 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
7758131 RGD
located in cleavage furrow IDA
IDA: Inferred from direct assay
8421057 RGD
located in microvillus IDA
IDA: Inferred from direct assay
8421057 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukosialin

W3/13 antigen

leukocyte sialoglycoprotein

leukosianin

Recombinant Spn Proteins

Cat. No. Product Name Accession Purity
HY-P75403 CD43 Protein, Rat (HEK293, Fc) R9PXZ7/NP_001258015.1 (Q21-S243) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107434 Molindone Antagonist / Unkown
Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149004 SLF1081851 Inhibitor 98.11% Unkown
HY-150254A SLB1122168 formic Inhibitor 99.91% Unkown
HY-162655 SLF80821178 99.70% Unkown
HY-150254 SLB1122168 Inhibitor / Unkown
HY-149004A SLF1081851 TFA Inhibitor / Unkown
HY-149004B SLF1081851 hydrochloride / Unkown
HY-156408 Spns2-IN-1 Inhibitor / Unkown
HY-162655A SLF80821178 hydrochloride Inhibitor / Unkown
HY-162996 Spns2-IN-2 Inhibitor / Unkown
HY-P10312 SPN009 Agonist / Unkown
HY-RS13689 SPN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13690 SPNS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13691 SPNS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13692 SPNS3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-107434S Molindone-d8 Inhibitor 99.2% Unkown
HY-12450 Lomofungin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spn NCBI NCBI:6693
Macaca fascicularis Spn NCBI NCBI:102147271
Mus musculus Spn NCBI NCBI:20737