SPN - sialophorin Gene

Homo sapiens

Also known as LSN; CD43; GALGP; GPL115; LEU-22

Gene ID: 6693 | Gene type: protein coding

About SPN

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,662,963-29,670,876 (from NCBI)

This gene has 6 transcripts (splice variants) and 82 orthologues. Biased expression in bone marrow (RPKM 10.2), lymph node (RPKM 6.8) and 13 other tissues.

Summary

This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]

SPN Products(2)

mRNA	Protein	Name
NM_001030288.4	NP_001025459.1	leukosialin precursor
NM_003123.6	NP_003114.1	leukosialin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	20633027	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	20633027	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T-helper 1 cell lineage commitment	IDA IDA: Inferred from direct assay	18036228	GOA
acts upstream of or within defense response to bacterium	IDA IDA: Inferred from direct assay	10899905	GOA
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	10899905	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	12354383	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	10899905	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leukosialin

galactoglycoprotein

SPN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPN	P16150	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	SPN	P16150	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	SPN	P16150	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	SPN	P16150	PPGB	Homo sapiens	Q59EV6	Validated Y2H	32296183
Intra	SPN	P16150	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	SPN	P16150	SGTA	Homo sapiens	O43765	Validated Y2H	32296183
Intra	SPN	P16150	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	SPN	P16150	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	SPN	P16150	PLP2	Homo sapiens	Q04941	Validated Y2H	32296183
Intra	SPN	P16150	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SPN	P16150	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SPN	P16150	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	SPN	P16150	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	SPN	P16150	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	SPN	P16150	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77887	CD43 Protein, Human (HEK293, His)	P16150 (S20-R253)	≥95%

Related Diseases

Diseases

Alias

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Aleukemic Monocytic Leukemia Cutis

Multicentric Papillary Thyroid Carcinoma

Multicentric Thyroid Gland Papillary Carcinoma

Chronic Inflammation Of Lacrimal Passage

Dacryocystocele

Lacrimal Mucocele

Mu Chain Disease

Mu-Chain Disease

Bladder Lymphoma

Lymphoma Of The Urinary Bladder

Aleukemic Leukemia Cutis

Myeloid Sarcoma

Granulocytic Sarcoma	Chloroma
Extramedullary Myeloid Tumor	Sarcoma, Granulocytic
Sarcoma Granulocytic	Sarcoma, Myeloid
Myelosarcoma	Myeloid Sarcoma Disease
Myeloid Sarcoma Nos	Myeloid Sarcoma Without Mention Of Remission

Hodgkin'S Lymphoma, Mixed Cellularity

Hodgkin'S Disease, Mixed Cellularity	Hodgkins Lymphoma, Mixed Cellularity
Mixed Cellularity Hodgkin Lymphoma

Esophagus Lymphoma

Lymphoma Of Esophagus	Lymphoma Of Oesophagus
Oesophagus Lymphoma	Esophageal Lymphoma

Bone Lymphoma

Lymphoma Of Bone

Lymphoma Of The Bone

Nodular Episcleritis

Lung Lymphoma

Pulmonary Lymphoma	Lymphoma Of Lung
Primary Lung Lymphoma

Ostertagiasis

Marginal Zone B-Cell Lymphoma

Marginal Zone Lymphoma	Mzl
Mucosa-Associated Lymphoid Tissue Lymphoma

Lethal Midline Granuloma

Granuloma, Lethal Midline	Malignant Granuloma Of Face
Midfacial Necrotising Lesion	Midline Lethal Granuloma

Breast Lymphoma

Lymphoma Of Breast	Lymphoma Of The Breast
Malignant Lymphoma Of Breast

Gastrointestinal Lymphoma

Nodal Marginal Zone Lymphoma

Mucosa-Associated Lymphoid Tissue Lymphoma

Monocytoid B-Cell Lymphoma

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Cll/Sll	B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Icdo:9823/3	Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission
Small Cell B-Cell Lymphoma

Spleen Cancer

Spleen Neoplasm	Splenic Neoplasm
Splenic Neoplasms	Malignant Splenic Tumor
Malignant Tumour Of Spleen	Tumor Of Spleen
Malignant Neoplasm Of Spleen

Splenic Marginal Zone Lymphoma

Smzl	Splenic Marginal Zone B-Cell Lymphoma

Composite Lymphoma

Composite Hodgkin And Non-Hodgkin Lymphoma

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Ureteral Lymphoma

Lymphoma Of Ureter

Ureter Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma	Lymphoma Of The Stomach
Primary Gastric Lymphoma

Epithelioid Cell Synovial Sarcoma

Synovial Sarcoma, Epithelioid Cell

Epithelioid Synovial Sarcoma

Lymphoplasmacytic Lymphoma

Waldenstrom Macroglobulinemia	Malignant Lymphoma - Lymphoplasmacytic
Waldenström Macroglobulinaemia	Waldenström Macroglobulinaemia Without Mention Of Remission
Idiopathic Macroglobulinaemia	Primary Macroglobulinaemia

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Infected Hydrocele

Pyocele

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Renal Pelvis Transitional Cell Carcinoma

Urothelial Cell Carcinoma Of Renal Pelvis	Renal Pelvis Urothelial Carcinoma
Transitional Cell Carcinoma Of Renal Pelvis

Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm	Neoplasm Of Mature B-Cells
Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Hemoglobin H Disease

HBH	Hemoglobin H Disease, Nondeletional
Hemoglobin H Disease, Deletional	Alpha-Thalassemia Intermedia
Haemoglobin H Disease	Alpha-Thalassemia, Hemoglobin H Type
Hemoglobin H Disease, Deletional And Nondeletional	Alpha Thalassemia, Haemoglobin H Type
Alpha Thalassemia, Hemoglobin H Type	Haemoglobin H Disease, Deletional
Hbh Disease	Alpha-Thalassemia Hemoglobin H Type
Hemoglobin H Disease Deletional	Hemoglobin H Disease Non-Deletional
Alpha-Thalassemia	Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia
Alpha Thalassaemia Intermedia

Appendix Lymphoma

Appendiceal Lymphoma

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107434	Molindone	Antagonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149004	SLF1081851	Inhibitor	98.11%	Unkown
HY-150254A	SLB1122168 formic	Inhibitor	99.91%	Unkown
HY-162655	SLF80821178		99.70%	Unkown
HY-150254	SLB1122168	Inhibitor	/	Unkown
HY-149004A	SLF1081851 TFA	Inhibitor	/	Unkown
HY-149004B	SLF1081851 hydrochloride		/	Unkown
HY-156408	Spns2-IN-1	Inhibitor	/	Unkown
HY-162655A	SLF80821178 hydrochloride	Inhibitor	/	Unkown
HY-162996	Spns2-IN-2	Inhibitor	/	Unkown
HY-P10312	SPN009	Agonist	/	Unkown
HY-RS13689	SPN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13690	SPNS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13691	SPNS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13692	SPNS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-107434S	Molindone-d8	Inhibitor	99.2%	Unkown
HY-12450	Lomofungin	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPN	VGNC	VGNC:35224
Rattus norvegicus	SPN	RGD	RGD:3750
Macaca mulatta	SPN	VGNC	VGNC:77861
Canis familiaris	SPN	VGNC	VGNC:58334
Mus musculus	SPN	MGD	MGI:98384
Macaca fascicularis	SPN	NCBI	NCBI:102147271
Others	SPN	NCBI