2. Gene
  3. Syt2 - synaptotagmin 2 Gene

Syt2 - synaptotagmin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as SYNII; RATSYNII

Gene ID: 24805 | Gene type: protein coding

About Syt2

Summary

Enables calcium-dependent phospholipid binding activity and syntaxin binding activity. Predicted to be involved in several processes, including positive regulation of dendrite extension; regulation of secretion by cell; and synaptic vesicle cycle. Located in terminal bouton. Is integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and congenital myasthenic syndrome 7. Orthologous to human SYT2 (synaptotagmin 2). [provided by Alliance of Genome Resources, Apr 2022]

Syt2 Products(1)

mRNA Protein Name
NM_012665.2 NP_036797.2 synaptotagmin-2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
7791877 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9303303 RGD
enables syntaxin binding IDA
IDA: Inferred from direct assay
7791877 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
9867811 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptotagmin-2

synaptotagmin II

sytII

Syt2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Syt2 P29101 WNK1 Homo sapiens Q9H4A3
Anti Tag CoIP
15350218
Intra
Syt2 P29101 Wnk1 Rattus norvegicus Q9JIH7
Biochemical
15350218
Intra
Syt2 P29101 Wnk1 Rattus norvegicus Q9JIH7
Anti Tag CoIP
15350218
Intra
Syt2 P29101 Wnk1 Rattus norvegicus Q9JIH7
Y2H
15350218
Cross
Syt2 P29101 botB Clostridium botulinum P10844
Pull Down
22265973
Cross
Syt2 P29101 botB Clostridium botulinum P10844
Pull Down
16545378
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14114 SYT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syt2 NCBI NCBI:127833