Tf - transferrin Gene

Rattus norvegicus

Also known as Tfn; Trf

Gene ID: 24825 | Gene type: protein coding

About Tf

Summary

Enables ferric iron binding activity. Involved in several processes, including cellular response to cAMP; cellular response to follicle-stimulating hormone stimulus; and regulation of nervous system development. Located in basement membrane; cell tip; and extracellular space. Used to study hepatitis. Biomarker of anemia and obesity. Human ortholog(s) of this gene implicated in anemia; atransferrinemia; glucose metabolism disease (multiple); iron deficiency anemia; and restless legs syndrome. Orthologous to human TF (transferrin). [provided by Alliance of Genome Resources, Apr 2022]

Tf Products(1)

mRNA	Protein	Name
NM_001013110.1	NP_001013128.1	serotransferrin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ferric iron binding	IDA IDA: Inferred from direct assay	17373738	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	17417667	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	15831523	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	15831523	RGD
involved in iron ion transport	IDA IDA: Inferred from direct assay	17373738	RGD
involved in positive regulation of myelination	IDA IDA: Inferred from direct assay	16480980	RGD
involved in positive regulation of oligodendrocyte progenitor proliferation	IDA IDA: Inferred from direct assay	23368675	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16479386	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	23007736	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16519141	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	1723977	RGD
located in cell tip	IDA IDA: Inferred from direct assay	17373738	RGD
located in dendrite	IDA IDA: Inferred from direct assay	26109571	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	17350134	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serotransferrin

beta-1 metal-binding globulin	liver regeneration-related protein LRRG03
siderophilin

Recombinant Tf Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73454	Transferrin Protein, Rat (HEK293, His)	P12346 (V20-S698)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18763	Indobufen	Inhibitor	99.98%	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P5533	CRT		99.96%	Phase 4
HY-P0171	Motixafortide	Antagonist	99.88%	Phase 3
HY-152963	Tisotumab vedotin		99.69%	Phase 3
HY-19284	FR-146687	Inhibitor	/	Phase 2
HY-N1992	Theaflavin 3,3'-digallate	Inhibitor	99.73%	Phase 1
HY-153480	ARC19499	Inhibitor	93.65%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99271	Tisotumab		≥95.0%	Phase 3
HY-P990090	Rademikibart	Inhibitor	98.69%	Phase 3

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100388	SHP099	Inhibitor	99.80%	Unkown
HY-134094	Fluridone		99.79%	Unkown
HY-148880	VHLL-BCN		96.30%	Unkown
HY-153480A	ARC19499 sodium	Inhibitor	93.65%	Unkown
HY-P5875A	P4pal10 TFA	Antagonist	98.25%	Unkown
HY-116170	SN34037		/	Unkown
HY-155951	JAK3-IN-14	Inhibitor	99.32%	Unkown
HY-156158	IDH2R140Q-IN-2	Inhibitor	/	Unkown
HY-162490	TF-S14	Inhibitor	/	Unkown
HY-169335	HIV-1 inhibitor-77	Inhibitor	/	Unkown
HY-170723	JAK-IN-39	Inhibitor	/	Unkown
HY-18763A	Indobufen sodium	Inhibitor	/	Unkown
HY-18763S	Indobufen-d5	Inhibitor	/	Unkown
HY-N10308	TF-DG-cThea		/	Unkown
HY-N10310	TF-3-G-cThea		/	Unkown
HY-P5152	Scorpion toxin Tf2	Activator	/	Unkown
HY-P5875	P4pal10	Antagonist	/	Unkown
HY-RS14406	TF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-13496	JNJ-28312141	Inhibitor	/	Unkown
HY-N10309	TF-3ʹ-G-cThea		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tf	NCBI	NCBI:7018
Canis familiaris	Tf	NCBI
Macaca fascicularis	Tf	NCBI	NCBI:101866521
Mus musculus	Tf	NCBI
Susscrofa domestica	Tf	NCBI
Leporidae	Tf	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.