2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. JNJ-28312141

JNJ-28312141 is an inhibitor for colony-stimulating factor-1 receptor (CSF-1R or FMS), with an IC50 of 0.69 nM. JNJ-28312141 inhibits proliferation of BDBM, MV-4-11, M-o7e, TF-1 with an IC50s of 2.6, 21, 41 and 150 nM, respectively. JNJ-28312141 exhibits anti-inflammatory activity in mouse arthritis model.

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JNJ-28312141 Chemical Structure

JNJ-28312141 Chemical Structure

CAS No. : 885692-52-4

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Description

JNJ-28312141 is an inhibitor for colony-stimulating factor-1 receptor (CSF-1R or FMS), with an IC50 of 0.69 nM. JNJ-28312141 inhibits proliferation of BDBM, MV-4-11, M-o7e, TF-1 with an IC50s of 2.6, 21, 41 and 150 nM, respectively. JNJ-28312141 exhibits anti-inflammatory activity in mouse arthritis model[1].

IC50 & Target

IC50: 0.69 nM (CSF-1R or FMS)
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
2600 nM
Compound: 23, JNJ-28312141
Inhibition of AXL overexpressed in human HEK cells assessed as inhibition of GAS6-induced autophosphorylation by immunoblot assay
Inhibition of AXL overexpressed in human HEK cells assessed as inhibition of GAS6-induced autophosphorylation by immunoblot assay
[PMID: 22039836]
Jurkat IC50
3900 nM
Compound: 23, JNJ-28312141
Inhibition of LCK in human Jurkat cells assessed as inhibition of PMA and antiCD3-induced IL2 secretion after 24 hrs by ELISA
Inhibition of LCK in human Jurkat cells assessed as inhibition of PMA and antiCD3-induced IL2 secretion after 24 hrs by ELISA
[PMID: 22039836]
MV4-11 IC50
21 nM
Compound: 23, JNJ-28312141
Inhibition of FLT3 in human MV411 cells assessed as inhibition of cell proliferation after 72 hrs by CellTiter-Glo assay
Inhibition of FLT3 in human MV411 cells assessed as inhibition of cell proliferation after 72 hrs by CellTiter-Glo assay
[PMID: 22039836]
Osteoclast IC50
1.7 nM
Compound: JNJ-28312141
Inhibition of RANKL-induced human osteoclast precursor cells differentiation in presence of human M-CSF and measured by tartrate-resistant acid phosphatase activity assay
Inhibition of RANKL-induced human osteoclast precursor cells differentiation in presence of human M-CSF and measured by tartrate-resistant acid phosphatase activity assay
[PMID: 35961461]
Osteoclast IC50
1.7 nM
Compound: JNJ-28312141
Inhibition of RANKL-induced human osteoclast precursor cells differentiation in presence of human CSF1 and measured by tartrate-resistant acid phosphatase activity assay
Inhibition of RANKL-induced human osteoclast precursor cells differentiation in presence of human CSF1 and measured by tartrate-resistant acid phosphatase activity assay
[PMID: 35961460]
TF-1 IC50
150 nM
Compound: 23, JNJ-28312141
Inhibition of TRKA in human TF1 cells assessed as inhibition of NGF-induced cell proliferation after 72 hrs by CellTiter-Glo assay
Inhibition of TRKA in human TF1 cells assessed as inhibition of NGF-induced cell proliferation after 72 hrs by CellTiter-Glo assay
[PMID: 22039836]
Molecular Weight

460.57

Formula

C26H32N6O2
CAS No.
SMILES

O=C(C1=NC(C#N)=CN1)NC2=C(C3=CCCCC3)C=C(C4CCN(C(CN(C)C)=O)CC4)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNJ-28312141 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-28312141885692-52-4JNJ28312141JNJ 28312141c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RRArheumatoid arthritisB6C3F1 mouseLewis ratMV-4-11M-o7eTF-1JurkatHEKInhibitorinhibitorinhibit

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