Thy1 - Thy-1 cell surface antigen Gene

Rattus norvegicus

Also known as CD7

Gene ID: 24832 | Gene type: protein coding

About Thy1

Summary

Enables GPI anchor binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including T cell receptor signaling pathway; focal adhesion assembly; and negative regulation of neuron projection development. Located in several cellular components, including growth cone; neuron projection membrane; and neuronal cell body membrane. Is anchored component of plasma membrane. Biomarker of retinal disease and retinal ischemia. Orthologous to human THY1 (Thy-1 cell surface antigen). [provided by Alliance of Genome Resources, Apr 2022]

Thy1 Products(1)

mRNA	Protein	Name
NM_012673.2	NP_036805.1	thy-1 membrane glycoprotein preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GPI anchor binding	IDA IDA: Inferred from direct assay	16257296	RGD
enables GTPase activator activity	IDA IDA: Inferred from direct assay	15093746	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	8666426	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10814697	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8870703	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9285719	RGD
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	9285719	RGD
acts upstream of or within positive effect cell-cell signaling	IDA IDA: Inferred from direct assay	22479590	RGD
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	15093746	RGD
involved in focal adhesion assembly	IDA IDA: Inferred from direct assay	15093746	RGD
involved in negative regulation of axonogenesis	IDA IDA: Inferred from direct assay	15547945	RGD
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	15093746	RGD
acts upstream of or within positive effect negative regulation of neuron projection regeneration	IMP IMP: Inferred from mutant phenotype	22479590	RGD
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	15093746	RGD
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	15093746	RGD
involved in positive regulation of T cell activation	IDA IDA: Inferred from direct assay	7722293	RGD
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	2873512	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	19723805	RGD
involved in receptor clustering	IDA IDA: Inferred from direct assay	22479590	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	20187850	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axolemma	IDA IDA: Inferred from direct assay	22479590	RGD
located in cell surface	IDA IDA: Inferred from direct assay	15474526	RGD
located in cytosol	IDA IDA: Inferred from direct assay	15547945	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	22479590	RGD
located in growth cone	IDA IDA: Inferred from direct assay	10601014	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	14499952	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	22479590	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	15547945	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

thy-1 membrane glycoprotein

CD90	Thy-1 protein
Thymus cell surface antigen	thy-1 antigen
thy-1 glycoprotein	thymus cell antigen 1, theta

Recombinant Thy1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74514	Thy1/CD90 Protein, Rat (HEK293, His)	P01830 (Q20-K129)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12953	R-268712	Inhibitor	99.88%	Unkown
HY-106611	Brinazarone	Inhibitor	/	Unkown
HY-RS14511	THY1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Thy1	NCBI	NCBI:7070
Macaca fascicularis	Thy1	NCBI	NCBI:102139037
Mus musculus	Thy1	NCBI	NCBI:21838

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