Cckar - cholecystokinin A receptor Gene

Rattus norvegicus

Also known as Cck-ar

Gene ID: 24889 | Gene type: protein coding

About Cckar

Primary_assembly 14: 57,292,397-57,300,747 forward strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 202 orthologues, 16 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 12.6), Liver (RPKM 3.7) and 4 other tissues.

Summary

Enables Cholecystokinin Receptor activity. Involved in several processes, including positive regulation of somatostatin secretion; reduction of food intake in response to dietary excess; and regulation of metal ion transport. Located in several cellular components, including endosome; lysosome; and terminal bouton. Used to study obesity and type 2 diabetes mellitus. Biomarker of pancreatic Cancer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Apr 2022]

Cckar Products(1)

mRNA	Protein	Name
NM_012688.3	NP_036820.1	cholecystokinin receptor type A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cholecystokinin receptor activity	IDA IDA: Inferred from direct assay	18776046	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	10403848	RGD
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	12649564	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	16728725	RGD
involved in feeding behavior	IDA IDA: Inferred from direct assay	12414437	RGD
involved in gastric acid secretion	IDA IDA: Inferred from direct assay	9773935	RGD
involved in insulin secretion	IDA IDA: Inferred from direct assay	9773935	RGD
involved in pancreas development	IEP IEP: Inferred from expression pattern	10403848	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	18776046	RGD
involved in positive regulation of somatostatin secretion	IMP IMP: Inferred from mutant phenotype	19959964	RGD
involved in reduction of food intake in response to dietary excess	IMP IMP: Inferred from mutant phenotype	12840200	RGD
involved in regulation of calcium ion transport	IDA IDA: Inferred from direct assay	11207382	RGD
involved in regulation of potassium ion transport	IDA IDA: Inferred from direct assay	12427859	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	7977738	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17622698	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	15127944	RGD
involved in response to starvation	IMP IMP: Inferred from mutant phenotype	12954406	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	16786113	RGD
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	15178543	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	9169450	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	3408996	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cckar Protein Structure

CholecysA-Rec_N

7tm_GPCRs

0
100
200
300
400
444 a.a.

Protein Preferred Names

Protein Names

cholecystokinin receptor type A

CCK-A receptor	CCK1-R
cholecystokinin-1 receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1096	A71623	Agonist	99.90%	Unkown
HY-B2154	Loxiglumide	Antagonist	≥98.0%	Unkown
HY-129810	PD 135158	Antagonist	/	Unkown
HY-123434	PD-149164	Agonist	/	Unkown
HY-119127	TP-680	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cckar	NCBI	NCBI:886

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