Prkcb - protein kinase C, beta Gene

Rattus norvegicus

Also known as Pkcb; Prkcb1

Gene ID: 25023 | Gene type: protein coding

About Prkcb

Primary_assembly 1: 176,832,226-177,163,536 forward strand.mRatBN7.2:CM026974.1

This gene has 8 transcripts (splice variants), 287 orthologues, 9 paralogues and is associated with 25 phenotypes. Biased expression in Brain (RPKM 562.1), Spleen (RPKM 51.2) and 6 other tissues.

Summary

Enables protein kinase C activity. Involved in several processes, including dibenzo-p-dioxin metabolic process; positive regulation of odontogenesis of dentin-containing tooth; and response to vitamin D. Located in brush border membrane; centrosome; and cytosol. Used to study hyperglycemia; hypertension; and silicosis. Biomarker of congestive heart failure; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcb Products(2)

mRNA	Protein	Name
NM_012713.4	NP_036845.3	protein kinase C beta type isoform 1
NM_001172305.1	NP_001165776.1	protein kinase C beta type isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7537734	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in dibenzo-p-dioxin metabolic process	IEP IEP: Inferred from expression pattern	16797713	RGD
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	11714718	RGD
involved in positive regulation of odontogenesis of dentin-containing tooth	IEP IEP: Inferred from expression pattern	15763930	RGD
involved in regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	15647254	RGD
involved in regulation of growth	IMP IMP: Inferred from mutant phenotype	3345563	RGD
involved in response to angiotensin	IDA IDA: Inferred from direct assay	11507002	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16997974	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	15030177	RGD
involved in response to vitamin D	IEP IEP: Inferred from expression pattern	10206343	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	15647254	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in brush border membrane	IDA IDA: Inferred from direct assay	17272350	RGD
located in centrosome	IDA IDA: Inferred from direct assay	14594954	RGD
located in cytosol	IDA IDA: Inferred from direct assay	11507002	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcb Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt2

C2_PKC_alpha_gamma

STKc_cPKC_beta

0
200
400
600
673 a.a.

Protein Preferred Names

Protein Names

protein kinase C beta type

PKC-beta	protein kinase C beta I
protein kinase C beta II	protein kinase C, beta 1

Prkcb Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Prkcb	P68403	Ptpra	Mus musculus	P18052	Protein Kinase Assay	7537734

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS11119	PRKCB Human Pre-designed siRNA Set A	/	Unkown
HY-RS11120	Prkcb Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11121	Prkcb Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkcb	NCBI	NCBI:5579

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