Gipr - gastric inhibitory polypeptide receptor Gene

Rattus norvegicus

Also known as Gippr; RATGIPPR

Gene ID: 25024 | Gene type: protein coding

About Gipr

Summary

Enables gastric inhibitory peptide receptor activity and peptide hormone binding activity. Involved in several processes, including desensitization of G protein-coupled receptor signaling pathway; positive regulation of cell communication; and response to glucose. Located in plasma membrane. Used to study type 2 diabetes mellitus. Biomarker of hyperglycemia. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; and obesity. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Apr 2022]

Gipr Products(2)

mRNA	Protein	Name
NM_012714.2	NP_036846.1	gastric inhibitory polypeptide receptor precursor
NM_012714.2	NP_036846.1	gastric inhibitory polypeptide receptor precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables gastric inhibitory peptide receptor activity	IDA IDA: Inferred from direct assay	8958204	RGD
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	8958204	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in desensitization of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	8928774	RGD
involved in gastric inhibitory peptide signaling pathway	IMP IMP: Inferred from mutant phenotype	11014226	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	8243312	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	11014226	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	19170165	RGD
involved in response to calcium ion	IMP IMP: Inferred from mutant phenotype	9705086	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	12475913	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	12475913	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gastric inhibitory polypeptide receptor

GIP-R	gastric inhibitory peptide receptor
glucose-dependent insulinotropic polypeptide receptor

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect Agonist	Purity	Phase Phase 3
HY-P3506	Retatrutide	Agonist	99.96%	Phase 3
HY-P3506A	Retatrutide TFA	Agonist	99.10%	Phase 3
HY-P3506B	Retatrutide acetate	Agonist	/	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect Inhibitor	Purity	Phase Phase 2
HY-P990047	Maridebart	Inhibitor	95.14%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect Agonist Pre-designed Sets	Purity	Rare Diseases Unkown
HY-P3584A	(Pro3) GIP, human TFA		99.79%	Unkown
HY-P10302A	GLP-1R/GIPR agonist-1 (soduim)	Agonist	96.55%	Unkown
HY-P10302	GLP-1R/GIPR agonist-1	Agonist	/	Unkown
HY-P3584	(Pro3) GIP, human	Agonist	99.79%	Unkown
HY-P10271	RG7697	Agonist	/	Unkown
HY-RS05437	GIPR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gipr	NCBI	NCBI:2696
Macaca fascicularis	Gipr	NCBI	NCBI:102123760
Mus musculus	Gipr	NCBI	NCBI:381853

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