2. GPCR/G Protein
  3. GLP Receptor
  4. RG7697

RG7697 is a dual agonist for glucagon-like peptide receptor (GLP Receptor) and glucosedependent insulinotropic polypeptide receptor (GIPR), with EC50 of 5 and 3 pM, respectively. RG7697 exhibits antihyperglycemic property.

For research use only. We do not sell to patients.

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RG7697 Chemical Structure

RG7697 Chemical Structure

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RG7697 Related Antibodies

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Description

RG7697 is a dual agonist for glucagon-like peptide receptor (GLP Receptor) and glucosedependent insulinotropic polypeptide receptor (GIPR), with EC50 of 5 and 3 pM, respectively. RG7697 exhibits antihyperglycemic property[1].

IC50 & Target

EC50: 3 pM (GIPR), 5 pM (GLP Receptor)
In Vivo

RG7697 (3-30 nmol/kg, s.c., daily for 7 days; or once every two weeks for 30 days) increases insulin secretion and metabolism, decreases glucose excursion, and ameliorates diet induced type 2 diabetes and obesity in C57BL/6 mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet induced type 2 diabete and obesity in C57BL/6 mice[1]
Dosage: 3-30 nmol/kg
Administration: s.c., daily for 7 days or once every week for 30 days
Result: Reduced body weight, blood glucose and food intake.
Decreased intraperitoneal glucose tolerance, plasma insulin and cholesterol.
Molecular Weight

4473.04

Formula

C211H316N46O61
Sequence

Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Tyr-Leu-Asp-Lys-Gln-Ala-Ala-{Aib}-Glu-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-{Lys(C16 acid)}-NH2
Sequence Shortening

Y-{Aib}-EGTFTSDYSIYLDKQAA-{Aib}-EFVNWLLAGGPSSGAPPPS-{Lys(C16 acid)}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RG7697 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RG7697RG 7697RG-7697GLP Receptortype 2 diabetesobesityC57BL/6 miceantihyperglycemicInhibitorinhibitorinhibit

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RG7697
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HY-P10271
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