ALPG - alkaline phosphatase, germ cell Gene

Homo sapiens

Also known as GCAP; ALPPL; ALPPL2

Gene ID: 251 | Gene type: protein coding

About ALPG

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,406,844-232,410,714 (from NCBI)

This gene has 1 transcript (splice variant), 361 orthologues and 3 paralogues. Biased expression in placenta (RPKM 6.1), lung (RPKM 0.8) and 1 other tissue.

Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated Enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of Alkaline Phosphatase. [provided by RefSeq, Jul 2008]

ALPG Products(1)

mRNA	Protein	Name
NM_031313.3	NP_112603.2	alkaline phosphatase, germ cell type preproprotein

ALPG Protein Structure

Alk_phosphatase

0
100
200
300
400
500
532 a.a.

Protein Preferred Names

Protein Names

alkaline phosphatase, germ cell type

ALP-1

Recombinant ALPG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700951	Alkaline Phosphatase/ALPG Protein, Human (Biotinylated, HEK293, His-Avi)	P10696 (I20-D503)	≥95%
HY-P700952	Alkaline Phosphatase/ALPG Protein, Human (HEK293, His)	P10696 (I20-D503)	≥95%

Related Diseases

Diseases

Alias

Seminoma

Seminoma, Pure

Gonadoblastoma

GBY

Germ Cell Cancer

Malignant Germ Cell Tumor	Neoplasms, Germ Cell And Embryonal
Germ Cell Neoplasm	Germ Cell Tumour
Malignant Tumor Of The Germ Cell	Neoplasms Germ Cell
Malignant Germ Cell Neoplasm

Mixed Type Thymoma

Thymoma, Mixed Type

Thymoma, Type Ab

Endodermal Sinus Tumor

Yolk Sac Tumor	Endodermal Sinus Tumour
Hepatoid Yolk Sac Tumour	Infantile Embryonal Carcinoma
Yolk Sac Neoplasm	Yolk Sac Tumour

Dysgerminoma

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Choriocarcinoma

Chorioepithelioma

Complete Androgen Insensitivity Syndrome

Cais	Complete Androgen Resistance Syndrome
Androgen Insensitivity Syndrome Complete	Androgen Insensitivity, Complete
Androgen-Insensitivity Syndrome	Testicular Feminization

Androgen Insensitivity Syndrome

Androgen Resistance Syndrome	AIS
Testicular Feminization Syndrome	Androgen Receptor Deficiency
Dhtr Deficiency	Dihydrotestosterone Receptor Deficiency
Ar Deficiency	Testicular Feminization
Tfm	Androgen Insensitivity
Androgen-Insensitivity Syndrome	Goldberg-Maxwell Syndrome
Complete Androgen Insensitivity Syndrome	Cais
Feminisation - Testicular	Goldberg - Maxwell Syndrome
Androgen Insensitivity Syndrome, Complete	Morris Syndrome
Ary	AR
Insensitivity Syndrome, Androgen	Androgen Insensitivity Nos

Testis Seminoma

Seminoma Of Testis	Seminoma Testis
Testicular Seminoma Pure	Seminoma

Hypophosphatasia

Phosphoethanolaminuria	Childhood Hypophosphatasia
Deficiency Of Alkaline Phosphatase	Hypophospatasia, Childhood
Hypophosphatasia Mild	Phosphoethanol-Aminuria
Rathburn Disease	Hpp
Rathbun Disease	Hypophosphatasia, Childhood
Infantile Hypophosphatasia

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00627	ALPG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALPG	RGD	RGD:1565100
Mus musculus	ALPG	NCBI
Others	ALPG	NCBI

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