2. Gene
  3. FUT3 - fucosyltransferase 3 (Lewis blood group) Gene

FUT3 - fucosyltransferase 3 (Lewis blood group) Gene

  • Gene
  • Protein
  • Disease
  • Agent
Homo sapiens

Also known as LE; Les; FT3B; CD174; FucT-III

Gene ID: 2525 | Gene type: protein coding

About FUT3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,842,888-5,857,122 (from NCBI)

This gene has 10 transcripts (splice variants), 384 orthologues, 7 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues.

Summary

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and Bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor Polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an Enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral Infection. [provided by RefSeq, Aug 2020]

FUT3 Products(12)

mRNA Protein Name
NM_000149.4 NP_000140.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097639.3 NP_001091108.3 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097640.3 NP_001091109.3 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097641.3 NP_001091110.3 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001374740.1 NP_001361669.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382744.1 NP_001369673.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382745.1 NP_001369674.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382746.1 NP_001369675.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382747.1 NP_001369676.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382748.2 NP_001369677.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382749.2 NP_001369678.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382750.2 NP_001369679.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IDA
IDA: Inferred from direct assay
1740457 GOA
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IMP
IMP: Inferred from mutant phenotype
10211701 GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
IDA: Inferred from direct assay
1740457 GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IMP
IMP: Inferred from mutant phenotype
10211701 GOA
enables alpha-(1->3)-fucosyltransferase activity IDA
IDA: Inferred from direct assay
1977660 GOA
enables fucosyltransferase activity IDA
IDA: Inferred from direct assay
7721776 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ceramide metabolic process IDA
IDA: Inferred from direct assay
7721776 GOA
involved in fucosylation IDA
IDA: Inferred from direct assay
1977660 GOA
involved in macromolecule glycosylation IDA
IDA: Inferred from direct assay
1977660 GOA
involved in oligosaccharide biosynthetic process IDA
IDA: Inferred from direct assay
1977660 GOA
involved in oligosaccharide metabolic process IDA
IDA: Inferred from direct assay
1740457 GOA
involved in positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
11058871 GOA
involved in protein N-linked glycosylation IDA
IDA: Inferred from direct assay
29593094 GOA
involved in protein O-linked glycosylation IDA
IDA: Inferred from direct assay
29593094 GOA
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
27453266 GOA
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
27453266 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
1977660 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUT3 Protein Structure

Glyco_transf_10

Glyco_transf_10: Glycosyltransferase family 10 (fucosyltransferase) C-term (16 - 360)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
Protein Preferred Names Protein Names

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3

FUT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FUT3 P21217 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
Intra
FUT3 P21217 SLC41A2 Homo sapiens Q96JW4
Validated Y2H
32296183
Intra
FUT3 P21217 FAM3B Homo sapiens P58499
Validated Y2H
32296183
Intra
FUT3 P21217 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Blood Group, Lewis System

LE

Lewis Blood Group System

Les
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05154 FUT3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown