LCLAT1 - lysocardiolipin acyltransferase 1 Gene

Homo sapiens

Also known as LYCAT; AGPAT8; ALCAT1; LPLAT6; 1AGPAT8; UNQ1849; HSRG1849

Gene ID: 253558 | Gene type: protein coding

About LCLAT1

Cytogenetic location: 2p23.1 Genomic coordinates (GRCh38): 2:30,447,246-30,644,225 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 4.7), duodenum (RPKM 3.7) and 25 other tissues.

Summary

Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

LCLAT1 Products(4)

mRNA	Protein	Name
NM_001002257.3	NP_001002257.1	lysocardiolipin acyltransferase 1 isoform 2
NM_001304445.2	NP_001291374.1	lysocardiolipin acyltransferase 1 isoform 2
NM_001304446.2	NP_001291375.1	lysocardiolipin acyltransferase 1 isoform 3
NM_182551.5	NP_872357.2	lysocardiolipin acyltransferase 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA IDA: Inferred from direct assay	16620771	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16620771	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCLAT1 Protein Structure

Acyltransferase

0
100
200
300
414 a.a.

Protein Preferred Names

Protein Names

lysocardiolipin acyltransferase 1

1-AGP acyltransferase 8

LCLAT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LCLAT1	Q6UWP7	GOPC	Homo sapiens	Q9HD26	Validated Y2H	25416956
Intra	LCLAT1	Q6UWP7	GOPC	Homo sapiens	Q9HD26	Y2H Array	25416956
Intra	LCLAT1	Q6UWP7	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	LCLAT1	Q6UWP7	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	LCLAT1	Q6UWP7	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	LCLAT1	Q6UWP7	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Barth Syndrome

3-Methylglutaconic Aciduria Type 2	BTHS
Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria	Mga Type Ii
Mga2	Mgca2
Mga Type 2	3-Methylglutaconic Aciduria Type Ii
3-Methylglutaconic Aciduria, Type Ii	Mga, Type Ii
3-Methylglutaconicaciduria Type 2	3-Methylglutaconicaciduria Type Ii
Taz Defect	3 Methylglutaconic Aciduria, Type Ii
Dnajc19 Defect	Cardioskeletal Myopathy-Neutropenia Syndrome
X-Linked Cardioskeletal Myopathy And Neutropenia	3-Alpha-Methylglutaconic Aciduria Type 2
Agm2	Cardioskeletal Myopathy-Neutropenia
Invm	Left Ventricular Non-Compaction Isolated X-Linked
Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked	Agammaglobulinemia 2, Autosomal Recessive

Mitochondrial Trifunctional Protein Deficiency

Tfp Deficiency	MTPD
Trifunctional Protein Deficiency	Trifunctional Protein Deficiency With Myopathy And Neuropathy
Tfpd	Familial Hypertrophic Cardiomyopathy
Cardiomyopathy Familial Hypertrophic	Familial Hcm
Heritable Hypertrophic Cardiomyopathy	Mtp Deficiency
Tpa Deficiency	Trifunctional Protein Deficiency, Type 2
Abetalipoproteinemia

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07551	LCLAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LCLAT1	VGNC	VGNC:107213
Rattus norvegicus	LCLAT1	RGD	RGD:1565906
Felis catus	LCLAT1	VGNC	VGNC:81111
Bos taurus	LCLAT1	VGNC	VGNC:30811
Canis familiaris	LCLAT1	VGNC	VGNC:42608
Mus musculus	LCLAT1	MGD	MGI:2684937

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