CERS6 - ceramide synthase 6 Gene

Homo sapiens

Also known as CERS5; LASS6

Gene ID: 253782 | Gene type: protein coding

About CERS6

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:168,456,272-168,775,134 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues and 5 paralogues. Ubiquitous expression in colon (RPKM 18.1), thyroid (RPKM 16.4) and 25 other tissues.

Summary

Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

CERS6 Products(2)

mRNA	Protein	Name
NM_001256126.2	NP_001243055.1	ceramide synthase 6 isoform 1
NM_203463.3	NP_982288.1	ceramide synthase 6 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28298427	GOA
enables sphingosine N-acyltransferase activity	IDA IDA: Inferred from direct assay	17609214	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ceramide biosynthetic process	IDA IDA: Inferred from direct assay	17609214	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CERS6 Protein Structure

Homeobox

TRAM_LAG1_CLN8

0
100
200
300
384 a.a.

Protein Preferred Names

Protein Names

ceramide synthase 6

LAG1 homolog, ceramide synthase 6

CERS6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CERS6	Q6ZMG9	OPRL1	Homo sapiens	P41146	Ub Reconstruction	28298427
Intra	CERS6	Q6ZMG9	AGTR1	Homo sapiens	P30556	Ub Reconstruction	28298427

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hereditary Sensory And Autonomic Neuropathy Type 1

Hereditary Sensory And Autonomic Neuropathy Type I	Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome
Hsan1e	Hsan1
Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy	Hsn1e
Hsnie	Hereditary Sensory Neuropathy Type Ie
Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome	Hereditary Sensory And Autonomic Neuropathy Type Ie
Hereditary Sensory And Autonomic Neuropathy Type 1e	Hereditary Sensory Neuropathy With Hearing Loss And Dementia
Dnmt1-Complex Disorder	Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss
Hsn Ie	Hereditary Sensory Autonomic Neuropathy, Type 1
Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19542	C6 Ceramide	Inducer	99.78%	Unkown
HY-146899S	CER6-2’R-d9		≥99.0%	Unkown
HY-146905S	CER6-2’S-d9		/	Unkown
HY-RS02541	CERS6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CERS6	MGD	MGI:2442564
Canis familiaris	CERS6	VGNC	VGNC:39152
Rattus norvegicus	CERS6	RGD	RGD:1561599
Felis catus	CERS6	VGNC	VGNC:107507
Bos taurus	CERS6	VGNC	VGNC:27228
Macaca mulatta	CERS6	VGNC	VGNC:71080
Others	CERS6	NCBI

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