RNF169 - ring finger protein 169 Gene

Homo sapiens

Gene ID: 254225 | Gene type: protein coding

About RNF169

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,748,849-74,842,413 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 6.7), bone marrow (RPKM 6.4) and 25 other tissues.

Summary

Enables K63-linked polyubiquitin modification-dependent protein binding activity and nucleosome binding activity. Involved in cellular response to DNA damage stimulus and negative regulation of double-strand break repair. Located in cytosol; nuclear lumen; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

RNF169 Products(1)

mRNA	Protein	Name
NM_001098638.2	NP_001092108.1	E3 ubiquitin-protein ligase RNF169

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables K63-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	22492721	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	22742833	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables ubiquitin-modified histone reader activity	IDA IDA: Inferred from direct assay	22492721	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	22733822	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	22492721	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	22492721	GOA
involved in negative regulation of double-strand break repair	IDA IDA: Inferred from direct assay	22742833	GOA
involved in negative regulation of double-strand break repair	IMP IMP: Inferred from mutant phenotype	22492721	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	22492721	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22733822	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	22492721	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF169 Protein Structure

zf-C3HC4_3

0
200
400
600
708 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF169

RING-type E3 ubiquitin transferase RNF169

Related Diseases

Diseases

Alias

Mixed Fibrolamellar Hepatocellular Carcinoma

Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7	Mental Retardation, Autosomal Dominant 7
Autosomal Dominant Non-Syndromic Intellectual Disability 7	Dyrk1a Syndrome
Autosomal Dominant Intellectual Developmental Disorder 7	Autosomal Dominant Mental Retardation 7
Mental Retardation, Autosomal Dominant, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12063	RNF169 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RNF169	VGNC	VGNC:34034
Felis catus	RNF169	VGNC	VGNC:104325
Canis familiaris	RNF169	VGNC	VGNC:45644
Macaca mulatta	RNF169	VGNC	VGNC:107634
Mus musculus	RNF169	MGD	MGI:1920257
Rattus norvegicus	RNF169	RGD	RGD:1583288

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