LCORL - ligand dependent nuclear receptor corepressor like Gene

Homo sapiens

Also known as MLR1

Gene ID: 254251 | Gene type: protein coding

About LCORL

Cytogenetic location: 4p15.31 Genomic coordinates (GRCh38): 4:17,841,187-18,021,875 (from NCBI)

This gene has 15 transcripts (splice variants), 96 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 2.1), small intestine (RPKM 1.8) and 25 other tissues.

Summary

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

LCORL Products(10)

mRNA	Protein	Name
NM_001166139.2	NP_001159611.1	ligand-dependent nuclear receptor corepressor-like protein isoform 1
NM_001365658.1	NP_001352587.1	ligand-dependent nuclear receptor corepressor-like protein isoform 3
NM_001365659.1	NP_001352588.1	ligand-dependent nuclear receptor corepressor-like protein isoform 3
NM_001365660.1	NP_001352589.1	ligand-dependent nuclear receptor corepressor-like protein isoform 4
NM_001365661.1	NP_001352590.1	ligand-dependent nuclear receptor corepressor-like protein isoform 5
NM_001365662.1	NP_001352591.1	ligand-dependent nuclear receptor corepressor-like protein isoform 6
NM_001365663.1	NP_001352592.1	ligand-dependent nuclear receptor corepressor-like protein isoform 7
NM_001365665.1	NP_001352594.1	ligand-dependent nuclear receptor corepressor-like protein isoform 8
NM_001394446.1	NP_001381375.1	ligand-dependent nuclear receptor corepressor-like protein isoform 9
NM_153686.8	NP_710153.2	ligand-dependent nuclear receptor corepressor-like protein isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone methyltransferase binding	IPI IPI: Inferred from physical interaction	29628311	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21900206	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCORL Protein Structure

HTH_psq

0
100
200
300
400
500
602 a.a.

Protein Preferred Names

Protein Names

ligand-dependent nuclear receptor corepressor-like protein

LCOR-like protein

Related Diseases

Diseases

Alias

Croup

Acute Obstructive Laryngitis	Laryngotracheobronchitis
Acute Laryngotracheobronchitis	Croup Syndrome
Acute Laryngitis With Obstruction	Obstructive Laryngitis
Obstructive Laryngitis Nos	Obstructive Laryngotracheitis Nos

Acromesomelic Dysplasia 2b

Fibular Hypoplasia And Complex Brachydactyly	Du Pan Syndrome
AMD2B	Dupans
Acromesomelic Dysplasia-2b	Fibular Aplasia-Complex Brachydactyly Syndrome

Acromesomelic Dysplasia

Acromesomelic Dwarfism	Dysplasia, Acromesomelic
Acromesomelic Dysplasia Hunter-Thompson Type

Osteochondrosis

Osteochondritis	Apophysitis
Epiphysitis	Osteochondritis Juvenilis
Epiphyseal Necrosis	Juvenile Osteochondrosis Of Tibial Tubercle

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07562	LCORL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LCORL	RGD	RGD:1561241
Felis catus	LCORL	VGNC	VGNC:78520
Mus musculus	LCORL	MGD	MGI:2651932
Canis familiaris	LCORL	VGNC	VGNC:59023
Macaca mulatta	LCORL	VGNC	VGNC:106624
Bos taurus	LCORL	VGNC	VGNC:30816

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