1. Gene
  2. CTBP1 - C-terminal binding protein 1 Gene

CTBP1 - C-terminal binding protein 1 Gene

Homo sapiens

Also known as BARS; HADDTS

Gene ID: 1487 | Gene type: protein coding

About CTBP1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,211,445-1,250,355 (from NCBI)

This gene has 23 transcripts (splice variants), 228 orthologues, 3 paralogues and is associated with 4 phenotypes. Ubiquitous expression in spleen (RPKM 9.3), prostate (RPKM 7.1) and 25 other tissues.

Summary

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CTBP1 Products(10)

mRNA Protein Name
NM_001012614.2 NP_001012632.1 C-terminal-binding protein 1 isoform 2
NM_001328.3 NP_001319.1 C-terminal-binding protein 1 isoform 1
NM_001377186.1 NP_001364115.1 C-terminal-binding protein 1 isoform 3
NM_001377187.1 NP_001364116.1 C-terminal-binding protein 1 isoform 4
NM_001377188.1 NP_001364117.1 C-terminal-binding protein 1 isoform 4
NM_001377189.1 NP_001364118.1 C-terminal-binding protein 1 isoform 4
NM_001377190.1 NP_001364119.1 C-terminal-binding protein 1 isoform 4
NM_001377191.1 NP_001364120.1 C-terminal-binding protein 1 isoform 2
NM_001377192.1 NP_001364121.1 C-terminal-binding protein 1 isoform 2
NM_001377193.1 NP_001364122.1 C-terminal-binding protein 1 isoform 2

CTBP1 Protein Structure

2-Hacid_dh

2-Hacid_dh: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (38 - 351)

2-Hacid_dh_C

2-Hacid_dh_C: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (134 - 317)

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  • 440 a.a.
Protein Preferred Names Protein Names

C-terminal-binding protein 1

brefeldin A-ribosylated substrate

CTBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CTBP1 Q13363 THAP11 Homo sapiens Q96EK4
Anti Tag CoIP
21988832
Intra
CTBP1 Q13363 THAP11 Homo sapiens Q96EK4
Anti Tag CoIP
31041561
Intra
CTBP1 Q13363 HIC1 Homo sapiens Q14526
Anti Bait CoIP
16762039
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
Anti Tag CoIP
33961781
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
GMS
28947780
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
Anti Tag CoIP
28514442
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
Proximity Labelling
35016035
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
Anti Tag CoIP
35271311
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
Anti Tag CoIP
31041561
Intra
CTBP1 Q13363 ZNF366 Homo sapiens Q8N895
Pull Down
17085477
Intra
CTBP1 Q13363 ZNF366 Homo sapiens Q8N895
Anti Tag CoIP
17085477
Intra
CTBP1 Q13363 ZNF366 Homo sapiens Q8N895
Y2H
17085477
Intra
CTBP1 Q13363 ZBTB18 Homo sapiens Q99592
Anti Tag CoIP
33961781
Intra
CTBP1 Q13363 ZBTB18 Homo sapiens Q99592
Y2H Array
24722188
Intra
CTBP1 Q13363 HEMGN Homo sapiens Q9BXL5
Y2H Array
21988832
Intra
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Anti Tag CoIP
33961781
Intra
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Anti Tag CoIP
28514442
Intra
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Anti Tag CoIP
31041561
Intra
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Y2H
21900206
Intra
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Proximity Labelling
35016035
Intra
CTBP1 Q13363 CBX4 Homo sapiens O00257
Anti Tag CoIP
33961781
Intra
CTBP1 Q13363 CBX4 Homo sapiens O00257
Anti Tag CoIP
28514442
Intra
CTBP1 Q13363 KLF4 Homo sapiens O43474
Anti Tag CoIP
19751731
Intra
CTBP1 Q13363 KLF4 Homo sapiens O43474
Anti Bait CoIP
19751731
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Anti Tag CoIP
35016035
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Anti Tag CoIP
33961781
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545
GMS
28947780
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Anti Tag CoIP
31041561
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Anti Tag CoIP
26496610
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Anti Tag CoIP
35271311
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Proximity Labelling
35016035
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Y2H Array
20211142
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Anti Tag CoIP
33961781
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Anti Tag CoIP
28514442
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Proximity Labelling
35016035
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Anti Tag CoIP
31041561
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Anti Tag CoIP
35271311
Intra
CTBP1 Q13363 RAI2 Homo sapiens Q9Y5P3
Y2H Array
24722188
Intra
CTBP1 Q13363 RAI2 Homo sapiens Q9Y5P3
Proximity Labelling
35016035
Intra
CTBP1 Q13363 RAI2 Homo sapiens Q9Y5P3
Anti Tag CoIP
35016035
Intra
CTBP1 Q13363 NRIP1 Homo sapiens P48552
Proximity Labelling
35016035
Intra
CTBP1 Q13363 NRIP1 Homo sapiens P48552
Y2H Array
24722188
Intra
CTBP1 Q13363 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
CTBP1 Q13363 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypotonia, Ataxia, Developmental Delay, And Tooth Enamel Defect Syndrome

HADDTS

Chromosome 4p Deletion

4p Partial Monosomy Syndrome

Chromosome 4 Short Arm Deletion

4p Deletion

4p Monosomy

Deletion 4p

Monosomy 4p

Partial Monosomy 4p

Wolf-Hirschhorn Syndrome

Chromosome 4 Short Arm Deletion Syndrome

Deletion Of Short Arm Of Chromosome 4

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome

WHS

Chromosome 4p16.3 Deletion Syndrome

Wittwer Syndrome

4p- Syndrome

Pitt Syndrome

4p Deletion Syndrome

Distal Deletion 4p

Distal Monosomy 4p

Telomeric Deletion 4p

Prds

4p Syndrome

Chromosome 4p Syndrome

Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation

Wolf Syndrome

Chromosome 4p Deletion Syndrome

Chromosome 4p Monosomy

Del Syndrome

Monosomy 4p

Partial Monosomy 4p

Chromosome 4 Short Arm Deletion

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Hypotonia
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Mowat-Wilson Syndrome

MOWS

Microcephaly, Mental Retardation, And Distinct Facial Features, With Or Without Hirschsprung Disease

Hirschsprung Disease-Mental Retardation Syndrome

Mowat-Wilson Syndrome Due To Monosomy 2q22

Hirschsprung Disease Mental Retardation Syndrome

Microcephaly, Mental Retardation, And Distinct Facial Featrues, With Or Without Hirschprung Disease

Hirschsprung Disease - Intellectual Disability Syndrome

Hirschsprung Disease Intellectual Disability Syndrome

Intellectual Disability, Microcephaly, And Distinct Facial Features With Or Without Hirschsprung Disease

Mws

Hirschsprung Disease-Intellectual Disability Syndrome

Hirschsprung Disease And Intellectual Disability Due To 2q22 Microdeletion

Hirschsprung Disease And Intellectual Disability Due To Del(2)(Q22)

Hirschsprung Disease And Intellectual Disability Due To Monosomy 2q22

Mowat-Wilson Syndrome Due To 2q22 Microdeletion

Mowat-Wilson Syndrome Due To Del(2)Q(22)

Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation

Hirschsprung Disease And Intellectual Disability Due To A Zeb2 Point Mutation

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CTBP1 RGD RGD:2441
Bos taurus CTBP1 VGNC VGNC:27785
Canis familiaris CTBP1 VGNC VGNC:39686
Macaca mulatta CTBP1 VGNC VGNC:71539
Mus musculus CTBP1 MGD MGI:1201685
Felis catus CTBP1 VGNC VGNC:61242