Gdnf - glial cell derived neurotrophic factor Gene

Rattus norvegicus

Also known as gndf

Gene ID: 25453 | Gene type: protein coding

About Gdnf

Summary

Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including animal organ development; cellular response to dexamethasone stimulus; and regulation of morphogenesis of an epithelium. Located in extracellular space. Part of receptor complex. Used to study Parkinsonism and middle cerebral artery infarction. Biomarker of Parkinsonism and sciatic neuropathy. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; and epilepsy. Orthologous to human GDNF (glial cell derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Gdnf Products(2)

mRNA	Protein	Name
NM_001401780.1	NP_001388709.1	glial cell line-derived neurotrophic factor isoform 2
NM_019139.2	NP_062012.2	glial cell line-derived neurotrophic factor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glial cell-derived neurotrophic factor receptor binding	IPI IPI: Inferred from physical interaction	10545102	RGD
enables growth factor activity	IDA IDA: Inferred from direct assay	12595497	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9187648	RGD
enables receptor ligand activity	IMP IMP: Inferred from mutant phenotype	10545102	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	10545102	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	17537984	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	22111653	RGD
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis	IDA IDA: Inferred from direct assay	17522159	RGD
involved in midbrain development	IEP IEP: Inferred from expression pattern	16650834	RGD
involved in negative regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22251670	RGD
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	32428552	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21311297	RGD
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	32428552	RGD
involved in neuron differentiation	IDA IDA: Inferred from direct assay	15109990	RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	17522159	RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17537984	RGD
involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	32428552	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	21311297	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	10545102	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	32428552	RGD
involved in regulation of ureteric bud formation	IDA IDA: Inferred from direct assay	19112489	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	16650834	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12595497	RGD
located in extracellular space	IMP IMP: Inferred from mutant phenotype	10545102	RGD
part of receptor complex	IDA IDA: Inferred from direct assay	15709767	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glial cell line-derived neurotrophic factor

ATF	Glial cell line derived neutrophic factor
astrocyte-derived trophic factor

Recombinant Gdnf Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73075	GDNF Protein, Rat (sf9, His)	Q07731-1 (S78-I211)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111969	BT18		99.77%	Unkown
HY-119910	(E)-Aminoquinol		99.70%	Unkown
HY-123439	FTY720-C2		/	Unkown
HY-RS05361	GDNF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119910B	Aminoquinol phosphate	Agonist	/	Unkown
HY-119910C	Aminoquinol triphosphate	Agonist	/	Unkown
HY-W101298S	(Leu-13C6,15N)-Ile-OH TFA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gdnf	NCBI	NCBI:2668
Canis familiaris	Gdnf	NCBI	NCBI:119871563
Mus musculus	Gdnf	NCBI	NCBI:14573

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