2. Gene
  3. Gdnf - glial cell line derived neurotrophic factor Gene

Gdnf - glial cell line derived neurotrophic factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ATF

Gene ID: 14573 | Gene type: protein coding

About Gdnf

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent Apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Homozygous knockout mice for this gene exhibit defects in kidney development and neonatal death. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

Gdnf Products(4)

mRNA Protein Name
NM_001301332.1 NP_001288261.1 glial cell line-derived neurotrophic factor isoform 2
NM_001301333.1 NP_001288262.1 glial cell line-derived neurotrophic factor isoform 3
NM_001301357.1 NP_001288286.1 glial cell line-derived neurotrophic factor isoform 4 preproprotein
NM_010275.3 NP_034405.1 glial cell line-derived neurotrophic factor isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within branching involved in ureteric bud morphogenesis IDA
IDA: Inferred from direct assay
13678594 MGI
involved in branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
8657307 MGI
involved in commissural neuron axon guidance IGI
IGI: Inferred from genetic interaction
22998873 MGI
involved in dorsal spinal cord development IMP
IMP: Inferred from mutant phenotype
22998873 MGI
involved in embryonic organ development IMP
IMP: Inferred from mutant phenotype
22998873 MGI
involved in enteric nervous system development IDA
IDA: Inferred from direct assay
8657308 MGI
involved in enteric nervous system development IMP
IMP: Inferred from mutant phenotype
8657306 MGI
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
IEP: Inferred from expression pattern
10322633 MGI
acts upstream of or within metanephros development IGI
IGI: Inferred from genetic interaction
15130495 MGI
acts upstream of or within metanephros development IMP
IMP: Inferred from mutant phenotype
17537792 MGI
involved in metanephros development IMP
IMP: Inferred from mutant phenotype
8657308 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15582775 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
8657308 MGI
acts upstream of or within organ induction IGI
IGI: Inferred from genetic interaction
15691764 MGI
acts upstream of or within peripheral nervous system development IMP
IMP: Inferred from mutant phenotype
11774071 MGI
acts upstream of or within peristalsis IMP
IMP: Inferred from mutant phenotype
11774071 MGI
involved in peristalsis IMP
IMP: Inferred from mutant phenotype
8657307 MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
17229286 MGI
involved in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IMP
IMP: Inferred from mutant phenotype
8657306 MGI
involved in postganglionic parasympathetic fiber development IMP
IMP: Inferred from mutant phenotype
8657307 MGI
acts upstream of or within postsynaptic membrane organization IDA
IDA: Inferred from direct assay
15381279 MGI
acts upstream of or within regulation of morphogenesis of a branching structure IDA
IDA: Inferred from direct assay
13678594 MGI
involved in regulation of semaphorin-plexin signaling pathway IGI
IGI: Inferred from genetic interaction
22998873 MGI
involved in sympathetic nervous system development IMP
IMP: Inferred from mutant phenotype
8657308 MGI
acts upstream of or within ureteric bud development IDA
IDA: Inferred from direct assay
15905075 MGI
acts upstream of or within ureteric bud development IGI
IGI: Inferred from genetic interaction
15691764 MGI
involved in ureteric bud formation IMP
IMP: Inferred from mutant phenotype
8657307 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glial cell line-derived neurotrophic factor

astrocyte-derived trophic factor

neurotrophic factor

Recombinant Gdnf Proteins

Cat. No. Product Name Accession Purity
HY-P7359 GDNF Protein, Mouse (CHO) P48540 (S78-I211) ≥95%
HY-P700179AF Animal-Free GDNF Protein, Mouse (His) P48540 (S78-I211) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111969 BT18 99.77% Unkown
HY-119910 (E)-Aminoquinol / Unkown
HY-123439 FTY720-C2 / Unkown
HY-RS05361 GDNF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-119910B Aminoquinol phosphate Agonist / Unkown
HY-119910C Aminoquinol triphosphate Agonist / Unkown
HY-W101298S (Leu-13C6,15N)-Ile-OH TFA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gdnf NCBI NCBI:2668
Canis familiaris Gdnf NCBI NCBI:119871563
Rattus norvegicus Gdnf NCBI NCBI:25453