Rab4a - RAB4A, member RAS oncogene family Gene

Rattus norvegicus

Also known as Rab4

Gene ID: 25532 | Gene type: protein coding

About Rab4a

Summary

Enables several functions, including ATPase binding activity; GTP binding activity; and ionotropic glutamate receptor binding activity. Involved in Rab protein signal transduction. Located in cytoplasmic vesicle; cytosol; and plasma membrane. Is anchored component of synaptic vesicle membrane. Orthologous to human RAB4A (RAB4A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab4a Products(1)

mRNA	Protein	Name
NM_013019.2	NP_037151.2	ras-related protein Rab-4A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	11062069	RGD
enables ATPase binding	IPI IPI: Inferred from physical interaction	11062069	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	8037667	RGD
enables GTPase activity	IDA IDA: Inferred from direct assay	9169411	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	17194442	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	23386062	RGD
enables syntaxin binding	IPI IPI: Inferred from physical interaction	11063739	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Rab protein signal transduction	IMP IMP: Inferred from mutant phenotype	9169411	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	8366094	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	10468577	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	20926670	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related protein Rab-4A

Ras-related small GTP binding protein 4

Rab4a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Rab4a	P05714	NISCH	Homo sapiens	Q9Y2I1	Pull Down	23386062

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11569	RAB4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab4a	NCBI	NCBI:5867

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