Slc6a4 - solute carrier family 6 member 4 Gene

Rattus norvegicus

Also known as SERT

Gene ID: 25553 | Gene type: protein coding

About Slc6a4

Primary_assembly 10: 61,826,123-61,858,384 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 205 orthologues, 20 paralogues and is associated with 54 phenotypes. Biased expression in Lung (RPKM 17.1), Adrenal (RPKM 71.6) and 4 other tissues.

Summary

Enables several functions, including cocaine binding activity; serotonin:sodium symporter activity; and syntaxin-1 binding activity. Involved in several processes, including cellular response to cGMP; cellular response to retinoic acid; and negative regulation of dopaminergic synaptic transmission. Located in several cellular components, including membrane raft; neuron projection; and synapse. Is active in serotonergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study anxiety disorder; mental depression; and pulmonary hypertension. Biomarker of Parkinsonism and borna disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a4 Products(1)

mRNA	Protein	Name
NM_013034.4	NP_037166.2	sodium-dependent serotonin transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	15627510	RGD
enables cocaine binding	IMP IMP: Inferred from mutant phenotype	15994310	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	10716733	RGD
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	8968583	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16870614	RGD
enables serotonin:sodium:chloride symporter activity	IDA IDA: Inferred from direct assay	1944572	RGD
enables serotonin:sodium:chloride symporter activity	IMP IMP: Inferred from mutant phenotype	8601815	RGD
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	11709063	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	18581099	RGD
involved in cellular response to cGMP	IDA IDA: Inferred from direct assay	17310063	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	17895527	RGD
involved in circadian rhythm	IMP IMP: Inferred from mutant phenotype	18482738	RGD
involved in conditioned place preference	IMP IMP: Inferred from mutant phenotype	18581099	RGD
involved in male mating behavior	IMP IMP: Inferred from mutant phenotype	20704641	RGD
involved in membrane depolarization	IDA IDA: Inferred from direct assay	14642278	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	20730799	RGD
involved in negative regulation of cerebellar granule cell precursor proliferation	IMP IMP: Inferred from mutant phenotype	18573488	RGD
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18573488	RGD
involved in negative regulation of synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	20730799	RGD
involved in positive regulation of serotonin secretion	IMP IMP: Inferred from mutant phenotype	25261262	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19168037	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	11259539	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	21068163	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20501324	RGD
involved in serotonin transport	IDA IDA: Inferred from direct assay	11709063	RGD
involved in serotonin transport	IMP IMP: Inferred from mutant phenotype	15994310	RGD
involved in serotonin uptake	IDA IDA: Inferred from direct assay	10716733	RGD
involved in vasoconstriction	IMP IMP: Inferred from mutant phenotype	14605793	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endomembrane system	IDA IDA: Inferred from direct assay	16870614	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	8601815	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	10460242	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	10460242	RGD
is active in serotonergic synapse	IDA IDA: Inferred from direct assay	10460242	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a4 Protein Structure

5HT_transport_N

SLC6sbd_SERT

0
100
200
300
400
500
630 a.a.

Protein Preferred Names

Protein Names

sodium-dependent serotonin transporter

5HT transporter	5HTT
Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)	serotonin transporter
solute carrier family 6 (neurotransmitter transporter), member 4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110023	Zimelidine dihydrochloride	Inhibitor	98.27%	Unkown
HY-RS13311	SLC6A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13312	Slc6a4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13313	Slc6a4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc6a4	NCBI	NCBI:6532

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