GABRG1 - gamma-aminobutyric acid type A receptor subunit gamma1 Gene

Homo sapiens

Gene ID: 2565 | Gene type: protein coding

About GABRG1

Cytogenetic location: 4p12 Genomic coordinates (GRCh38): 4:46,035,769-46,124,054 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues and 45 paralogues. Restricted expression toward brain (RPKM 11.0).

Summary

The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral Chloride Channel. This gene is clustered with three Other family members on chromosome 4. [provided by RefSeq, Jul 2008]

GABRG1 Products(1)

mRNA	Protein	Name
NM_173536.4	NP_775807.2	gamma-aminobutyric acid receptor subunit gamma-1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GABRG1 Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
465 a.a.

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor subunit gamma-1

GABA(A) receptor subunit gamma-1

GABRG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GABRG1	Q8N1C3	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	GABRG1	Q8N1C3	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	GABRG1	Q8N1C3	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Substance Dependence

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05220	GABRG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GABRG1	RGD	RGD:621732
Canis familiaris	GABRG1	VGNC	VGNC:41063
Macaca mulatta	GABRG1	VGNC	VGNC:72856
Bos taurus	GABRG1	VGNC	VGNC:55048
Felis catus	GABRG1	VGNC	VGNC:78501
Mus musculus	GABRG1	MGD	MGI:103156

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