2. Gene
  3. NEGR1 - neuronal growth regulator 1 Gene

NEGR1 - neuronal growth regulator 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Ntra; KILON; IGLON4; DMML2433

Gene ID: 257194 | Gene type: protein coding

About NEGR1

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:71,395,943-72,282,539 (from NCBI)

This gene has 5 transcripts (splice variants), 213 orthologues and 5 paralogues. Broad expression in brain (RPKM 13.7), fat (RPKM 5.3) and 18 other tissues.

Summary

Predicted to act upstream of or within several processes, including feeding behavior; locomotory behavior; and positive regulation of neuron projection development. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NEGR1 Products(1)

mRNA Protein Name
NM_173808.3 NP_776169.2 neuronal growth regulator 1 precursor

NEGR1 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (46 - 135)

I-set

I-set: Immunoglobulin I-set domain (139 - 209)

I-set

I-set: Immunoglobulin I-set domain (228 - 312)

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  • 354 a.a.
Protein Preferred Names Protein Names

neuronal growth regulator 1

IgLON family member 4

Recombinant NEGR1 Proteins

Cat. No. Product Name Accession Purity
HY-P76508 NEGR1 Protein, Human (HEK293, His) Q7Z3B1-1 (V38-G324) ≥95%

Related Diseases

Diseases Alias
Niemann-Pick Disease, Type C2

NPC2

Niemann-Pick Disease Type C2

Niemann-Pick C2 Disease

Niemann-Pick Disease C2
Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis

Niemann-Pick Diseases

Lipoid Histiocytosis

Sphingomyelin Lipidosis

Sphingomyelinase Deficiency Disease

Lipid Histiocytosis

Neuronal Cholesterol Lipidosis

Neuronal Lipidosis

Npd

Sphingomyelinase Deficiency

Niemann-Pick Disease, Type A
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09186 NEGR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NEGR1 RGD RGD:708416
Bos taurus NEGR1 VGNC VGNC:106836
Mus musculus NEGR1 MGD MGI:2444846
Macaca mulatta NEGR1 VGNC VGNC:81481
Felis catus NEGR1 VGNC VGNC:107589
Canis familiaris NEGR1 VGNC VGNC:54049
Others NEGR1 NCBI