RASGRP3 - RAS guanyl releasing protein 3 Gene

Homo sapiens

Also known as GRP3

Gene ID: 25780 | Gene type: protein coding

About RASGRP3

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:33,436,348-33,564,731 (from NCBI)

This gene has 18 transcripts (splice variants), 198 orthologues and 24 paralogues. Broad expression in lymph node (RPKM 8.7), appendix (RPKM 6.4) and 22 other tissues.

Summary

The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]

RASGRP3 Products(10)

mRNA	Protein	Name
NM_001139488.2	NP_001132960.1	ras guanyl-releasing protein 3 isoform 1
NM_001349975.2	NP_001336904.1	ras guanyl-releasing protein 3 isoform 1
NM_001349976.2	NP_001336905.1	ras guanyl-releasing protein 3 isoform 1
NM_001349977.2	NP_001336906.1	ras guanyl-releasing protein 3 isoform 1
NM_001349978.2	NP_001336907.1	ras guanyl-releasing protein 3 isoform 2
NM_001349979.2	NP_001336908.1	ras guanyl-releasing protein 3 isoform 2
NM_001349980.2	NP_001336909.1	ras guanyl-releasing protein 3 isoform 2
NM_001349981.2	NP_001336910.1	ras guanyl-releasing protein 3 isoform 2
NM_015376.3	NP_056191.1	ras guanyl-releasing protein 3 isoform 2
NM_170672.3	NP_733772.1	ras guanyl-releasing protein 3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	10934204	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASGRP3 Protein Structure

RasGEF_N

RasGEF

EF-hand_6

EF-hand_5

C1_1

0
200
400
600
690 a.a.

Protein Preferred Names

Protein Names

ras guanyl-releasing protein 3

CalDAG-GEFIII

RASGRP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RASGRP3	Q8IV61	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	RASGRP3	Q8IV61	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	RASGRP3	Q8IV61	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	RASGRP3	Q8IV61	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	RASGRP3	Q8IV61	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	RASGRP3	Q8IV61	DYNLL2	Homo sapiens	Q96FJ2	Validated Y2H	25416956
Intra	RASGRP3	Q8IV61	DYNLL2	Homo sapiens	Q96FJ2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11695	RASGRP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-123977	RasGRP3 ligand 1	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RASGRP3	VGNC	VGNC:33749
Canis familiaris	RASGRP3	VGNC	VGNC:45373
Rattus norvegicus	RASGRP3	RGD	RGD:1304612
Felis catus	RASGRP3	VGNC	VGNC:64502
Macaca mulatta	RASGRP3	VGNC	VGNC:106206
Mus musculus	RASGRP3	MGD	MGI:3028579

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