HSD17B11 - hydroxysteroid 17-beta dehydrogenase 11 Gene

Homo sapiens

Also known as DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI

Gene ID: 51170 | Gene type: protein coding

About HSD17B11

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,336,515-87,391,188 (from NCBI)

This gene has 7 transcripts (splice variants), 122 orthologues and 25 paralogues. Broad expression in small intestine (RPKM 142.3), duodenum (RPKM 102.8) and 22 other tissues.

Summary

Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]

HSD17B11 Products(1)

mRNA	Protein	Name
NM_016245.5	NP_057329.3	estradiol 17-beta-dehydrogenase 11 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA IDA: Inferred from direct assay	12697717	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables steroid dehydrogenase activity	IDA IDA: Inferred from direct assay	12697717	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in androgen catabolic process	IDA IDA: Inferred from direct assay	12697717	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12697717	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	14741744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSD17B11 Protein Structure

adh_short

0
100
200
300 a.a.

Protein Preferred Names

Protein Names

estradiol 17-beta-dehydrogenase 11

17-beta-hydroxysteroid dehydrogenase type XI

HSD17B11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSD17B11	Q8NBQ5	SLC25A46	Homo sapiens	Q96AG3	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	TVP23B	Homo sapiens	Q9NYZ1	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	SLC22A18	Homo sapiens	Q96BI1	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	GIMAP1	Homo sapiens	Q8WWP7	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	FAM241B	Homo sapiens	Q96D05-2	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	LNPEP	Homo sapiens	Q9UIQ6-2	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	TMEM203	Homo sapiens	Q969S6	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	HTATIP2	Homo sapiens	Q9BUP3-3	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	AGPAT4	Homo sapiens	Q9NRZ5	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	TMEM167B	Homo sapiens	Q9NRX6	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	AGPAT3	Homo sapiens	Q9NRZ7	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	RMDN2	Homo sapiens	Q96LZ7	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	OTULINL	Homo sapiens	Q9NUU6	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	NEU1	Homo sapiens	Q99519	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	CMTM3	Homo sapiens	Q96MX0	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	HSD17B11	Q8NBQ5	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06391	HSD17B11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HSD17B11	MGD	MGI:2149821
Rattus norvegicus	HSD17B11	RGD	RGD:1303235
Bos taurus	HSD17B11	VGNC	VGNC:29970
Macaca mulatta	HSD17B11	VGNC	VGNC:73431
Felis catus	HSD17B11	VGNC	VGNC:62846

Name
Email *

	Sorry, but the email address you supplied was invalid.