QPCT - glutaminyl-peptide cyclotransferase Gene

Homo sapiens

Also known as QC; GCT; sQC

Gene ID: 25797 | Gene type: protein coding

About QPCT

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,344,630-37,373,322 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 1 paralogue. Biased expression in adrenal (RPKM 75.9), bone marrow (RPKM 17.6) and 13 other tissues.

Summary

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine Peptides. The amino acid sequence of this Enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]

QPCT Products(1)

mRNA	Protein	Name
NM_012413.4	NP_036545.1	glutaminyl-peptide cyclotransferase precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutaminyl-peptide cyclotransferase activity	IDA IDA: Inferred from direct assay	21288892	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	21288892	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase	IDA IDA: Inferred from direct assay	21288892	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QPCT Protein Structure

Peptidase_M28

0
100
200
300
361 a.a.

Protein Preferred Names

Protein Names

glutaminyl-peptide cyclotransferase

Recombinant QPCT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76560	QPCT Protein, Human (sf9, His)	Q16769-1 (A33-L361)	≥95%

Related Diseases

Diseases

Alias

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British	Fbd
Presenile Dementia With Spastic Ataxia	Familial British Dementia
Abri Amyloidosis	Cerebral Amyloid Angiopathy, British Type
Itm2b-Related Cerebral Amyloid Angiopathy 1	Familial Dementia, British Type
Cerebral Amyloid Angiopathy, Itm2b-Related 1	CAA-ITM2B1
Cerebral Amyloid Angiopathy British Type	Dementia, Familial, British

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136780	SEN177	Inhibitor	97.10%	Unkown
HY-RS11501	QPCT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	QPCT	VGNC	VGNC:33598
Mus musculus	QPCT	MGD	MGI:1917786
Macaca mulatta	QPCT	VGNC	VGNC:76636
Felis catus	QPCT	VGNC	VGNC:69199
Rattus norvegicus	QPCT	RGD	RGD:1562284
Canis familiaris	QPCT	VGNC	VGNC:45233
Others	QPCT	NCBI

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