SAMM50 - SAMM50 sorting and assembly machinery component Gene

Homo sapiens

Also known as OMP85; SAM50; TOB55; TRG-3; CGI-51; YNL026W

Gene ID: 25813 | Gene type: protein coding

About SAMM50

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:43,955,442-43,996,529 (from NCBI)

This gene has 6 transcripts (splice variants) and 269 orthologues. Ubiquitous expression in fat (RPKM 26.2), duodenum (RPKM 21.9) and 25 other tissues.

Summary

This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011]

SAMM50 Products(1)

mRNA	Protein	Name
NM_015380.5	NP_056195.3	sorting and assembly machinery component 50 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21081504	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cristae formation	IMP IMP: Inferred from mutant phenotype	22252321	GOA
involved in mitochondrial respiratory chain complex assembly	IMP IMP: Inferred from mutant phenotype	22252321	GOA
involved in protein insertion into mitochondrial outer membrane	IDA IDA: Inferred from direct assay	15644312	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SAM complex	IMP IMP: Inferred from mutant phenotype	15644312	GOA
part of SAM complex	IPI IPI: Inferred from physical interaction	17510655	GOA
located in membrane	IDA IDA: Inferred from direct assay	15644312	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	15644312	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15644312	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAMM50 Protein Structure

Bac_surface_Ag

0
100
200
300
400
469 a.a.

Protein Preferred Names

Protein Names

sorting and assembly machinery component 50 homolog

sorting and assembly machinery 50kDa

SAMM50 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SAMM50	Q9Y512	CHCHD6	Homo sapiens	Q9BRQ6	Y2H Prey Pooling	32296183
Intra	SAMM50	Q9Y512	MFN2	Homo sapiens	O95140	Anti Tag CoIP	27059175
Intra	SAMM50	Q9Y512	DNM1L	Homo sapiens	O00429	Anti Tag CoIP	27059175
Intra	SAMM50	Q9Y512	CHCHD3	Homo sapiens	Q9NX63	Y2H Prey Pooling	25416956
Intra	SAMM50	Q9Y512	CHCHD3	Homo sapiens	Q9NX63	Validated Y2H	25416956
Intra	SAMM50	Q9Y512	CHCHD3	Homo sapiens	Q9NX63	Y2H Prey Pooling	32296183
Intra	SAMM50	Q9Y512	CHCHD3	Homo sapiens	Q9NX63	Y2H Array	25416956
Intra	SAMM50	Q9Y512	CHCHD3	Homo sapiens	Q9NX63	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Glanders

Farcy Pipes	Infection Due To Pseudomonas Mallei
Burkholderia Mallei	Burkholderia Mallei Infection
Equina	Equine Glanders
Farcy	Farcy Buds
Farcy Cords	Infection Due To Actinobacillus Mallei
Infection Due To Malleomyces Mallei	Maliasmus
Malleus	Farce
Actinobacillosis	Actinobacillus Infection

Sennetsu Fever

Sennetsu Ehrlichiosis

Human Ehrlichial Infection, Sennetsu Type

Retinitis Pigmentosa 44

RP44	Retinitis Pigmentosa, Type 44

Urethral Syndrome

Urethral Disease	Urethral Diseases
Urethra Disease	Abnormality Of The Urethra
Urethral Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12434	SAMM50 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SAMM50	VGNC	VGNC:77095
Bos taurus	SAMM50	VGNC	VGNC:34278
Canis familiaris	SAMM50	VGNC	VGNC:54542
Rattus norvegicus	SAMM50	RGD	RGD:1303219
Mus musculus	SAMM50	MGD	MGI:1915903

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