GALR1 - galanin receptor 1 Gene

Homo sapiens

Also known as GALNR; GALNR1

Gene ID: 2587 | Gene type: protein coding

About GALR1

Cytogenetic location: 18q23 Genomic coordinates (GRCh38): 18:77,249,848-77,277,900 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues and 16 paralogues. Biased expression in adrenal (RPKM 1.2), brain (RPKM 0.7) and 7 other tissues.

Summary

The neuropeptide Galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]

GALR1 Products(1)

mRNA	Protein	Name
NM_001480.4	NP_001471.2	galanin receptor type 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables galanin receptor activity	IDA IDA: Inferred from direct assay	24517231	GOA
enables peptide hormone binding	IDA IDA: Inferred from direct assay	24517231	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23597562	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cortisol secretion	IMP IMP: Inferred from mutant phenotype	17982695	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24517231	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALR1 Protein Structure

7tm_1

0
100
200
300
349 a.a.

Protein Preferred Names

Protein Names

galanin receptor type 1

GAL1-R

Related Diseases

Diseases

Alias

Chromosome 18q Deletion Syndrome

18q- Syndrome	Monosomy 18q
Deletion Of Long Arm Of Chromosome 18	Chromosome 18q- Syndrome
Deletion 18q	18q Deletion Syndrome
Distal 18q Deletion Syndrome	Chromosome 18 Long Arm Deletion Syndrome
Chromosome 18q Monosomy	Del Syndrome
Chromosome 18 Deletion Syndrome

Auditory Agnosia

Benign Essential Hypertension

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Lynch Syndrome I

Lynch Syndrome 1	Colorectal Cancer, Hereditary Nonpolyposis, Type 1
HNPCC1	Fcc1
Lynch Syndrome Ii	Colon Cancer, Familial Nonpolyposis, Type 1
Coca1	Familial Nonpolyposis Colon Cancer Type 1
Hereditary Nonpolyposis Colorectal Cancer Type 1	Hereditary Non-Polyposis Colorectal Cancer 1
Hereditary Non-Polyposis Colorectal Cancer 3	Hnpcc3
Lynch Cancer Family Syndrome	Lynch Syndrome
Lynch Syndrome Type I	Lynch Syndrome Type Ii
Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1	Hereditary Nonpolyposis Colorectal Cancer
Colorectal Cancer, Hereditary Nonpolyposis, Type 3	Hereditary Non-Polyposis Colon Cancer Type 2

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1127	Galanin (1-30), human	Agonist	99.90%	Unkown
HY-P1130	M871	Antagonist	99.80%	Unkown
HY-123671	CYM2503	Modulator	96.01%	Unkown
HY-P5064	Galanin-Like Peptide (porcine)	Agonist	/	Unkown
HY-P5894	human GALP (3-32)	Antagonist	/	Unkown
HY-RS05264	GALR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-139799	Sch 202596	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GALR1	VGNC	VGNC:29239
Canis familiaris	GALR1	VGNC	VGNC:41100
Macaca mulatta	GALR1	VGNC	VGNC:104222
Mus musculus	GALR1	MGD	MGI:1096364
Rattus norvegicus	GALR1	RGD	RGD:2656
Felis catus	GALR1	VGNC	VGNC:62456

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