2. Gene
  3. GALNT2 - polypeptide N-acetylgalactosaminyltransferase 2 Gene

GALNT2 - polypeptide N-acetylgalactosaminyltransferase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CDG2T; GalNAc-T2

Gene ID: 2590 | Gene type: protein coding

About GALNT2

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:230,057,789-230,282,122 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues, 19 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 16.5), appendix (RPKM 14.3) and 25 other tissues.

Summary

This gene encodes a member of the Glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of Peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GALNT2 Products(2)

mRNA Protein Name
NM_001291866.2 NP_001278795.1 polypeptide N-acetylgalactosaminyltransferase 2 isoform 2
NM_004481.5 NP_004472.1 polypeptide N-acetylgalactosaminyltransferase 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables manganese ion binding IDA
IDA: Inferred from direct assay
9295285 GOA
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
IDA: Inferred from direct assay
9295285 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21699783 GOA
Biological Process GO Annotation Evidence Reference Source
involved in O-glycan processing IDA
IDA: Inferred from direct assay
18562306 GOA
involved in protein O-linked glycosylation IDA
IDA: Inferred from direct assay
16434399 GOA
involved in protein O-linked glycosylation via serine IDA
IDA: Inferred from direct assay
9295285 GOA
involved in protein O-linked glycosylation via threonine IDA
IDA: Inferred from direct assay
9295285 GOA
involved in protein maturation IDA
IDA: Inferred from direct assay
12438318 GOA
Cellular Component GO Annotation Evidence Reference Source
colocalizes with Golgi apparatus IDA
IDA: Inferred from direct assay
12506059 GOA
located in Golgi apparatus IDA
IDA: Inferred from direct assay
9852147 GOA
located in Golgi stack IDA
IDA: Inferred from direct assay
9852147 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12506059 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALNT2 Protein Structure

Glycos_transf_2

Glycos_transf_2: Glycosyl transferase family 2 (139 - 303)

Ricin_B_lectin

Ricin_B_lectin: Ricin-type beta-trefoil lectin domain (453 - 563)

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  • 500
  • 571 a.a.
Protein Preferred Names Protein Names

polypeptide N-acetylgalactosaminyltransferase 2

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2

GALNT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GALNT2 Q10471 MRM3 Homo sapiens Q9HC36
Y2H Prey Pooling
32296183
Intra
GALNT2 Q10471 MRM3 Homo sapiens Q9HC36
Y2H Array
32296183
Intra
GALNT2 Q10471 MRM3 Homo sapiens Q9HC36
Validated Y2H
32296183
Intra
GALNT2 Q10471 COQ9 Homo sapiens O75208
Y2H Prey Pooling
32296183
Intra
GALNT2 Q10471 COQ9 Homo sapiens O75208
Y2H Array
32296183
Intra
GALNT2 Q10471 BCL2L13 Homo sapiens Q9BXK5
Validated Y2H
32296183
Intra
GALNT2 Q10471 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra
GALNT2 Q10471 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra
GALNT2 Q10471 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
GALNT2 Q10471 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
GALNT2 Q10471 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GALNT2 Proteins

Cat. No. Product Name Accession Purity
HY-P76355 GALNT2 Protein, Human (HEK293, His) Q10471-1/NP_004472.1 (K52-Q571) ≥95%

Related Diseases

Diseases Alias
Congenital Disorder Of Glycosylation, Type Iit

CDG2T

Cdg Iit

Cdgiit

Congenital Disorder Of Glycosylation 2t
Methylmalonic Aciduria, Cblb Type

Methylmalonic Aciduria Cblb Type

Methylmalonic Acidemia Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type

Methylmalonic Acidemia, Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type

Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb

Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb

Methylmalonic Aciduria Type Cblb

MMAB

Methylmalonic Aciduria Type B

Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B

Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B

Aciduria, Methylmalonic, Cblb Type

Methylmalonic Acidemia

Methylmalonic Aciduria
Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation

CDG1N

Congenital Disorders Of Glycosylation

Cdg In

Cdgin

Congenital Disorder Of Glycosylation 1n

Carbohydrate-Deficient Glycoprotein Syndrome

Cdg

Rft1-Cdg

Cdg-In

Congenital Disorder Of Glycosylation Type In

Carbohydrate Deficient Glycoprotein Syndrome

Cdg Syndrome

Congenital Disorder Of Glycosylation In

Carbohydrate-Deficient Glycoprotein Syndromes

Cdg Syndrome Type In

Carbohydrate Deficient Glycoprotein Syndrome Type In

Congenital Disorder Of Glycosylation Type 1n

Man5glcnac2-Pp-Dol Flippase Deficiency

Glycosylation, Congenital Disorder Of

Glycosylation, Congenital Disorder Of, Type In
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-E70139 UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2 / Unkown
HY-RS01301 B3GALNT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01316 B4GALNT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05256 GALNT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GALNT2 VGNC VGNC:29231
Canis familiaris GALNT2 VGNC VGNC:41094
Rattus norvegicus GALNT2 RGD RGD:1310692
Felis catus GALNT2 VGNC VGNC:62450
Macaca mulatta GALNT2 VGNC VGNC:72872
Mus musculus GALNT2 MGD MGI:894694
Others GALNT2 NCBI