ALS2CL - ALS2 C-terminal like Gene

Homo sapiens

Also known as RN49018

Gene ID: 259173 | Gene type: protein coding

About ALS2CL

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,668,995-46,693,679 (from NCBI)

This gene has 10 transcripts (splice variants), 129 orthologues and 7 paralogues. Broad expression in skin (RPKM 30.9), esophagus (RPKM 10.4) and 18 other tissues.

Summary

Enables identical protein binding activity. Acts upstream of or within endosome organization. Predicted to be located in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

ALS2CL Products(2)

mRNA	Protein	Name
NM_001190707.2	NP_001177636.1	ALS2 C-terminal-like protein isoform 1
NM_147129.5	NP_667340.2	ALS2 C-terminal-like protein isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALS2CL Protein Structure

MORN

VPS9

0
200
400
600
800
953 a.a.

Protein Preferred Names

Protein Names

ALS2 C-terminal-like protein

ALS2CL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ALS2CL	Q60I27	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	ALS2CL	Q60I27	EEF1AKMT3	Homo sapiens	Q96AZ1	Validated Y2H	32296183
Intra	ALS2CL	Q60I27	RAB22A	Homo sapiens	Q9UL26	Validated Y2H	32296183
Intra	ALS2CL	Q60I27	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 6

DFNB6	Neurosensory Nonsyndromic Recessive Deafness 6
Nsrd6	Autosomal Recessive Nonsyndromic Deafness 6
Autosomal Recessive Deafness 6	Deafness, Autosomal Recessive, 6
Deafness Neurosensory Autosomal Recessive 6	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 6
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 6	Deafness, Autosomal Recessive, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00635	ALS2CL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALS2CL	RGD	RGD:1305208
Felis catus	ALS2CL	VGNC	VGNC:59761
Canis familiaris	ALS2CL	VGNC	VGNC:54571
Mus musculus	ALS2CL	MGD	MGI:2447532
Macaca mulatta	ALS2CL	VGNC	VGNC:69649
Bos taurus	ALS2CL	VGNC	VGNC:25852

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