RAB22A - RAB22A, member RAS oncogene family Gene

Homo sapiens

Gene ID: 57403 | Gene type: protein coding

About RAB22A

Cytogenetic location: 20q13.32 Genomic coordinates (GRCh38): 20:58,309,715-58,367,507 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 68 paralogues. Ubiquitous expression in brain (RPKM 7.8), adrenal (RPKM 6.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]

RAB22A Products(1)

mRNA	Protein	Name
NM_020673.3	NP_065724.1	ras-related protein Rab-22A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	24466322	GOA
enables GTPase activity	IMP IMP: Inferred from mutant phenotype	24466322	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11870209	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytosis	IDA IDA: Inferred from direct assay	11870209	GOA
involved in endosome organization	IEP IEP: Inferred from expression pattern	11870209	GOA
involved in regulation of vesicle size	IMP IMP: Inferred from mutant phenotype	24466322	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	11870209	GOA
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	21255211	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11870209	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB22A Protein Structure

Ras

0
100
194 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-22A

GTP-binding protein RAB22A

RAB22A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB22A	Q9UL26	ALS2CL	Homo sapiens	Q60I27	Y2H Array	32296183
Intra	RAB22A	Q9UL26	ALS2CL	Homo sapiens	Q60I27	Y2H Prey Pooling	32296183
Intra	RAB22A	Q9UL26	EEA1	Homo sapiens	Q15075	Y2H	11870209
Intra	RAB22A	Q9UL26	APPL2	Homo sapiens	Q8NEU8	Y2H Array	31515488
Intra	RAB22A	Q9UL26	APPL2	Homo sapiens	Q8NEU8	Validated Y2H	25416956
Intra	RAB22A	Q9UL26	APPL2	Homo sapiens	Q8NEU8	Y2H Prey Pooling	32296183
Intra	RAB22A	Q9UL26	APPL2	Homo sapiens	Q8NEU8	Y2H Array	25416956
Intra	RAB22A	Q9UL26	APPL2	Homo sapiens	Q8NEU8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RAB22A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82046	Rab22A Antibody (YA1791)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Exocervical Carcinoma

Carcinoma Of Exocervix

Carcinoma Of The Exocervix

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11532	RAB22A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RAB22A	VGNC	VGNC:45262
Rattus norvegicus	RAB22A	RGD	RGD:1311959
Macaca mulatta	RAB22A	VGNC	VGNC:81522
Bos taurus	RAB22A	VGNC	VGNC:33629
Mus musculus	RAB22A	MGD	MGI:105072

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