ZDHHC5 - zinc finger DHHC-type palmitoyltransferase 5 Gene

Homo sapiens

Also known as DHHC5; ZNF375

Gene ID: 25921 | Gene type: protein coding

About ZDHHC5

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,668,114-57,701,182 (from NCBI)

This gene has 8 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 30.1), thyroid (RPKM 23.7) and 25 other tissues.

Summary

Enables palmitoyltransferase activity. Involved in positive regulation of pattern recognition receptor signaling pathway and positive regulation of protein localization to plasma membrane. Acts upstream of or within protein palmitoylation. Located in phagocytic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC5 Products(1)

mRNA	Protein	Name
NM_015457.3	NP_056272.2	palmitoyltransferase ZDHHC5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables palmitoyltransferase activity	IDA IDA: Inferred from direct assay	22325201	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31402609	GOA
enables protein-cysteine S-palmitoyltransferase activity	IDA IDA: Inferred from direct assay	29185452	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	38092000	GOA
involved in positive regulation of pattern recognition receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	31649195	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	31649195	GOA
involved in positive regulation of pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	38530158	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	31649195	GOA
acts upstream of or within protein palmitoylation	IDA IDA: Inferred from direct assay	22325201	GOA
involved in protein palmitoylation	IDA IDA: Inferred from direct assay	23034182	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	31649195	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16647879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC5 Protein Structure

DHHC

0
200
400
600
715 a.a.

Protein Preferred Names

Protein Names

palmitoyltransferase ZDHHC5

DHHC-5

ZDHHC5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZDHHC5	Q9C0B5	GOLGA7B	Homo sapiens	Q2TAP0	Anti Tag CoIP	31402609
Intra	ZDHHC5	Q9C0B5	GOLGA7B	Homo sapiens	Q2TAP0	Confocal	31402609
Cross	ZDHHC5	Q9C0B5	S	SARS-CoV-2	P0DTC2	Anti Tag CoIP	34117209
Cross	ZDHHC5	Q9C0B5	S	SARS-CoV-2	P0DTC2	Y2H Array	36217030

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lung Acinar Adenocarcinoma

Acinar Adenocarcinoma Of The Lung

Lung Papillary Adenocarcinoma

Papillary Lung Adenocarcinoma

Papillary Adenocarcinoma Of The Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16022	ZDHHC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZDHHC5	MGD	MGI:1923573
Bos taurus	ZDHHC5	VGNC	VGNC:37143
Macaca mulatta	ZDHHC5	VGNC	VGNC:79145
Felis catus	ZDHHC5	VGNC	VGNC:67216
Rattus norvegicus	ZDHHC5	RGD	RGD:1589737

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