CLIC4 - chloride intracellular channel 4 Gene

Homo sapiens

Also known as H1; huH1; p64H1; CLIC4L; MTCLIC

Gene ID: 25932 | Gene type: protein coding

About CLIC4

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:24,745,447-24,844,321 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 14 paralogues. Ubiquitous expression in endometrium (RPKM 129.1), kidney (RPKM 121.8) and 25 other tissues.

Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic Cancer cells). [provided by RefSeq, Jul 2008]

CLIC4 Products(1)

mRNA	Protein	Name
NM_013943.3	NP_039234.1	chloride intracellular channel protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10793131	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	17636002	GOA
involved in keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	17636002	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	12163372	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	14569596	GOA
located in cell surface	IDA IDA: Inferred from direct assay	14569596	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	14569596	GOA
located in centrosome	IDA IDA: Inferred from direct assay	14569596	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10793131	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10026142	GOA
colocalizes with microtubule cytoskeleton	IDA IDA: Inferred from direct assay	14569596	GOA
located in microvillus	IDA IDA: Inferred from direct assay	14569596	GOA
located in midbody	IDA IDA: Inferred from direct assay	14569596	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	14569596	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	14569596	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14569596	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19776349	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLIC4 Protein Structure

GST_N_3

0
100
200
253 a.a.

Protein Preferred Names

Protein Names

chloride intracellular channel protein 4

chloride intracellular channel 4 like

CLIC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CLIC4	Q9Y696	TPRN	Homo sapiens	Q4KMQ1-2	Anti Tag CoIP	28514442
Intra	CLIC4	Q9Y696	TPRN	Homo sapiens	Q4KMQ1-2	Y2H Array	32296183
Intra	CLIC4	Q9Y696	TPRN	Homo sapiens	Q4KMQ1-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLIC4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70120	CLIC4/Chloride intracellular channel 4 Protein, Human (His)	Q9Y696 (M1-K253)	≥95%

CLIC4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82772	CLIC4 Antibody (YA2517)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02806	CLIC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CLIC4	RGD	RGD:61857
Macaca mulatta	CLIC4	VGNC	VGNC:71172
Mus musculus	CLIC4	MGD	MGI:1352754
Bos taurus	CLIC4	VGNC	VGNC:27442
Canis familiaris	CLIC4	VGNC	VGNC:39340
Others	CLIC4	NCBI

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