2. Gene
  3. ADGRA2 - adhesion G protein-coupled receptor A2 Gene

ADGRA2 - adhesion G protein-coupled receptor A2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TEM5; GPR124

Gene ID: 25960 | Gene type: protein coding

About ADGRA2

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:37,796,883-37,844,896 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 42 paralogues. Broad expression in prostate (RPKM 39.9), fat (RPKM 36.6) and 23 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Involved in positive regulation of canonical Wnt signaling pathway. Part of Wnt signalosome. [provided by Alliance of Genome Resources, Apr 2022]

ADGRA2 Products(1)

mRNA Protein Name
NM_032777.10 NP_116166.9 adhesion G protein-coupled receptor A2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15021905 GOA
Biological Process GO Annotation Evidence Reference Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
30026314 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Wnt signalosome IDA
IDA: Inferred from direct assay
30026314 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRA2 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (88 - 144)

HRM

HRM: Hormone receptor domain (365 - 418)

GPS

GPS: GPCR proteolysis site, GPS, motif (708 - 753)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (780 - 947)

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  • 1338 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor A2

G-protein coupled receptor 124

ADGRA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ADGRA2 Q96PE1 DLG1 Homo sapiens Q12959-2
Anti Tag CoIP
15021905
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Kidney Leiomyosarcoma

Leiomyosarcoma Of Kidney
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
Norrie Disease

Atrophia Bulborum Hereditaria

Episkopi Blindness

Pseudoglioma

ND

Norrie-Warburg Disease

Anderson-Warburg Syndrome

Fetal Iritis Syndrome

Norrie Syndrome

Norrie-Warburg Syndrome

Ndp

Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

Norrie'S Disease

Oligophrenia Microphthalmus

Pseudoglioma Congenita

Whitnall-Norman Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00343 ADGRA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ADGRA2 VGNC VGNC:69453
Mus musculus ADGRA2 MGD MGI:1925810
Felis catus ADGRA2 VGNC VGNC:59628
Bos taurus ADGRA2 VGNC VGNC:106631
Rattus norvegicus ADGRA2 RGD RGD:2323365
Canis familiaris ADGRA2 VGNC VGNC:37632