2. Gene
  3. MOXD1 - monooxygenase DBH like 1 Gene

MOXD1 - monooxygenase DBH like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MOX; PRO5780; dJ248E1.1

Gene ID: 26002 | Gene type: protein coding

About MOXD1

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,296,055-132,401,475 (from NCBI)

This gene has 4 transcripts (splice variants), 176 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 34.3), adrenal (RPKM 21.6) and 17 other tissues.

Summary

Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Part of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

MOXD1 Products(1)

mRNA Protein Name
NM_015529.4 NP_056344.2 DBH-like monooxygenase protein 1 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
15337741 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOXD1 Protein Structure

DOMON

DOMON: DOMON domain (34 - 148)

Cu2_monooxygen

Cu2_monooxygen: Copper type II ascorbate-dependent monooxygenase, N-terminal domain (186 - 316)

Cu2_monoox_C

Cu2_monoox_C: Copper type II ascorbate-dependent monooxygenase, C-terminal domain (333 - 485)

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  • 613 a.a.
Protein Preferred Names Protein Names

DBH-like monooxygenase protein 1

dopamine-oxygenase

MOXD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MOXD1 Q6UVY6 GLRX3 Homo sapiens O76003
Y2H Array
32296183
Intra
MOXD1 Q6UVY6 GLRX3 Homo sapiens O76003
Y2H Array
29892012
Intra
MOXD1 Q6UVY6 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
Intra
MOXD1 Q6UVY6 GPAA1 Homo sapiens O43292
Anti Tag CoIP
33961781
Intra
MOXD1 Q6UVY6 GPAA1 Homo sapiens O43292
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neuroaspergillosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08605 MOXD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MOXD1 VGNC VGNC:63568
Canis familiaris MOXD1 VGNC VGNC:43329
Macaca mulatta MOXD1 VGNC VGNC:74800
Bos taurus MOXD1 VGNC VGNC:31568
Rattus norvegicus MOXD1 RGD RGD:1310033
Mus musculus MOXD1 MGD MGI:1921582