TKFC - triokinase and FMN cyclase Gene

Homo sapiens

Also known as DAK; NET45; TKFCD

Gene ID: 26007 | Gene type: protein coding

About TKFC

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,333,228-61,353,426 (from NCBI)

This gene has 21 transcripts (splice variants), 191 orthologues and is associated with 3 phenotypes. Broad expression in duodenum (RPKM 30.4), small intestine (RPKM 22.4) and 23 other tissues.

Summary

This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017]

TKFC Products(6)

mRNA	Protein	Name
NM_001351976.2	NP_001338905.1	triokinase/FMN cyclase isoform b
NM_001351977.2	NP_001338906.1	triokinase/FMN cyclase isoform a
NM_001351978.2	NP_001338907.1	triokinase/FMN cyclase isoform c
NM_001351979.2	NP_001338908.1	triokinase/FMN cyclase isoform d
NM_001351980.2	NP_001338909.1	triokinase/FMN cyclase isoform e
NM_015533.4	NP_056348.2	triokinase/FMN cyclase isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables FAD-AMP lyase (cyclizing) activity	IDA IDA: Inferred from direct assay	16289032	GOA
enables glycerone kinase activity	IDA IDA: Inferred from direct assay	4688871	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17600090	GOA
enables triokinase activity	IDA IDA: Inferred from direct assay	4688871	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in carbohydrate metabolic process	IDA IDA: Inferred from direct assay	4688871	GOA
involved in carbohydrate phosphorylation	IDA IDA: Inferred from direct assay	4688871	GOA
involved in negative regulation of MDA-5 signaling pathway	IDA IDA: Inferred from direct assay	17600090	GOA
involved in regulation of innate immune response	IDA IDA: Inferred from direct assay	16289032	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

triokinase/FMN cyclase

ATP-dependent dihydroxyacetone kinase

Related Diseases

Diseases

Alias

Triokinase And Fmn Cyclase Deficiency Syndrome

TKFCD

Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10	Cardiomyopathy And Cataract
Cataract And Cardiomyopathy	MTDPS10
Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome	Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10
Senger Syndrome

Inherited Metabolic Disorder

Inborn Errors Of Metabolism	Inborn Metabolic Disorder
Inborn Metabolism Disorder	Metabolic Hereditary Disorder
Inborn Error Of Metabolism	Metabolism, Inborn Errors

Squamous Cell Bile Duct Carcinoma

Bile Duct Squamous Cell Carcinoma

Lung Combined Type Small Cell Carcinoma

Combined Small Cell Carcinoma Of The Lung

Combined Type Small Cell Carcinoma Of Lung

Microcytic Anemia

Iron-Refractory Iron Deficiency Anemia

Fructosuria, Essential

Essential Fructosuria	Ketohexokinase Deficiency
Fructosuria	Hepatic Fructokinase Deficiency
Fructokinase Deficiency	FRUCT
Deficiency Of Fructokinase

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14558	TKFC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TKFC	VGNC	VGNC:66202
Canis familiaris	TKFC	VGNC	VGNC:47390
Bos taurus	TKFC	VGNC	VGNC:56287
Macaca mulatta	TKFC	VGNC	VGNC:79441
Rattus norvegicus	TKFC	RGD	RGD:1311026
Mus musculus	TKFC	MGD	MGI:2385084

Name
Email *

	Sorry, but the email address you supplied was invalid.