RPAP1 - RNA polymerase II associated protein 1 Gene

Homo sapiens

Gene ID: 26015 | Gene type: protein coding

About RPAP1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,517,176-41,544,257 (from NCBI)

This gene has 12 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in testis (RPKM 6.0), ovary (RPKM 4.6) and 25 other tissues.

Summary

This protein forms part of the RNA polymerase II (RNAPII) Enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012]

RPAP1 Products(1)

mRNA	Protein	Name
NM_015540.4	NP_056355.2	RNA polymerase II-associated protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPAP1 Protein Structure

RPAP1_N

RPAP1_C

0
300
600
900
1200
1393 a.a.

Protein Preferred Names

Protein Names

RNA polymerase II-associated protein 1

RPAP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPAP1	Q9BWH6	POLR2L	Homo sapiens	P62875	Y2H Prey Pooling	25416956
Intra	RPAP1	Q9BWH6	POLR2L	Homo sapiens	P62875	Validated Y2H	25416956
Intra	RPAP1	Q9BWH6	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myasthenic Syndrome, Congenital, 22

CMS22	Prepl Deficiency
Congenital Myasthenic Syndrome 22

Sporotrichosis

Rose Gardener'S Disease

Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease	2p21 Microdeletion Syndrome
HCS	Homozygous 2p16 Deletion Syndrome, Formerly
2p21 Deletion Syndrome	Del(2)(P21)
Monosomy 2p21	Atypical Hypotonia-Cystinuria Syndrome
Atypical Hcs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12147	RPAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPAP1	VGNC	VGNC:34098
Canis familiaris	RPAP1	VGNC	VGNC:45706
Mus musculus	RPAP1	MGD	MGI:1916175
Rattus norvegicus	RPAP1	RGD	RGD:1590891
Macaca mulatta	RPAP1	VGNC	VGNC:76813
Felis catus	RPAP1	VGNC	VGNC:64728
Others	RPAP1	NCBI

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