IPCEF1 - interaction protein for cytohesin exchange factors 1 Gene

Homo sapiens

Also known as PIP3E; PIP3-E

Gene ID: 26034 | Gene type: protein coding

About IPCEF1

Cytogenetic location: 6q25.2 Genomic coordinates (GRCh38): 6:154,154,496-154,356,803 (from NCBI)

This gene has 13 transcripts (splice variants), 97 orthologues and 4 paralogues. Biased expression in thyroid (RPKM 13.5), brain (RPKM 6.8) and 9 other tissues.

Summary

Predicted to enable peroxidase activity. Predicted to be involved in response to oxidative stress. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

IPCEF1 Products(7)

mRNA	Protein	Name
NM_001130699.2	NP_001124171.1	interactor protein for cytohesin exchange factors 1 isoform 1
NM_001130700.2	NP_001124172.1	interactor protein for cytohesin exchange factors 1 isoform 1
NM_001394799.1	NP_001381728.1	interactor protein for cytohesin exchange factors 1 isoform 1
NM_001394800.1	NP_001381729.1	interactor protein for cytohesin exchange factors 1 isoform 1
NM_001394801.1	NP_001381730.1	interactor protein for cytohesin exchange factors 1 isoform 1
NM_001394802.1	NP_001381731.1	interactor protein for cytohesin exchange factors 1 isoform 2
NM_015553.3	NP_056368.1	interactor protein for cytohesin exchange factors 1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22085542	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IPCEF1 Protein Structure

0
100
200
300
400
437 a.a.

Protein Preferred Names

Protein Names

interactor protein for cytohesin exchange factors 1

interaction protein for cytohesin exchange factors 1 Interaction protein for cytohesin exchange factors 1

IPCEF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IPCEF1	Q8WWN9	CYTH4	Homo sapiens	Q9UIA0	Y2H Prey Pooling	32296183
Intra	IPCEF1	Q8WWN9	CYTH4	Homo sapiens	Q9UIA0	Validated Y2H	32296183
Intra	IPCEF1	Q8WWN9	CYTH4	Homo sapiens	Q9UIA0	Anti Tag CoIP	33961781
Intra	IPCEF1	Q8WWN9	CYTH4	Homo sapiens	Q9UIA0	Y2H Array	32296183
Intra	IPCEF1	Q8WWN9	CYTH2	Homo sapiens	Q99418	Y2H Array	32296183
Intra	IPCEF1	Q8WWN9	CYTH2	Homo sapiens	Q99418	Anti Tag CoIP	33961781
Intra	IPCEF1	Q8WWN9	CYTH2	Homo sapiens	Q99418	Y2H Prey Pooling	32296183
Intra	IPCEF1	Q8WWN9	CYTH2	Homo sapiens	Q99418	Validated Y2H	32296183
Intra	IPCEF1	Q8WWN9	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	IPCEF1	Q8WWN9	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	IPCEF1	Q8WWN9	CYTH1	Homo sapiens	Q15438	Y2H Prey Pooling	32296183
Intra	IPCEF1	Q8WWN9	CYTH1	Homo sapiens	Q15438	Anti Tag CoIP	33961781
Intra	IPCEF1	Q8WWN9	CYTH1	Homo sapiens	Q15438	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06864	IPCEF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IPCEF1	VGNC	VGNC:30239
Mus musculus	IPCEF1	MGD	MGI:2444159
Macaca mulatta	IPCEF1	VGNC	VGNC:83429
Rattus norvegicus	IPCEF1	RGD	RGD:735159

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