CYTH1 - cytohesin 1 Gene

Homo sapiens

Also known as B2-1; SEC7; PSCD1; D17S811E; CYTOHESIN-1

Gene ID: 9267 | Gene type: protein coding

About CYTH1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,674,048-78,782,273 (from NCBI)

This gene has 17 transcripts (splice variants), 280 orthologues and 15 paralogues. Ubiquitous expression in lymph node (RPKM 26.6), bone marrow (RPKM 23.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with Phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

CYTH1 Products(12)

mRNA	Protein	Name
NM_001292018.4	NP_001278947.1	cytohesin-1 isoform 3
NM_001292019.4	NP_001278948.1	cytohesin-1 isoform 3
NM_001365037.2	NP_001351966.1	cytohesin-1 isoform 4
NM_001365038.2	NP_001351967.1	cytohesin-1 isoform 5
NM_001365039.2	NP_001351968.1	cytohesin-1 isoform 5
NM_001365040.2	NP_001351969.1	cytohesin-1 isoform 6
NM_001365041.3	NP_001351970.1	cytohesin-1 isoform 5
NM_001394676.1	NP_001381605.1	cytohesin-1 isoform 5
NM_001394677.1	NP_001381606.1	cytohesin-1 isoform 7
NM_001394678.1	NP_001381607.1	cytohesin-1 isoform 8
NM_004762.6	NP_004753.1	cytohesin-1 isoform 1
NM_017456.4	NP_059430.2	cytohesin-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	10652308	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11867758	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within regulation of cell adhesion	IDA IDA: Inferred from direct assay	12606567	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12606567	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12606567	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYTH1 Protein Structure

Sec7

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

cytohesin-1

PH, SEC7 and coiled-coil domain-containing protein 1

CYTH1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CYTH1	Q15438	IPCEF1	Homo sapiens	Q8WWN9	Y2H Prey Pooling	32296183
Intra	CYTH1	Q15438	IPCEF1	Homo sapiens	Q8WWN9	Validated Y2H	32296183
Intra	CYTH1	Q15438	IPCEF1	Homo sapiens	Q8WWN9	Y2H Array	32296183
Intra	CYTH1	Q15438	INAVA	Homo sapiens	Q3KP66-1	BRET	31022698
Intra	CYTH1	Q15438	INAVA	Homo sapiens	Q3KP66-1	Y2H	31022698
Intra	CYTH1	Q15438	CNKSR1	Homo sapiens	Q969H4	Validated Y2H	32296183
Intra	CYTH1	Q15438	CNKSR1	Homo sapiens	Q969H4	Anti Tag CoIP	33961781
Intra	CYTH1	Q15438	CNKSR1	Homo sapiens	Q969H4	Y2H Prey Pooling	32296183
Intra	CYTH1	Q15438	CNKSR1	Homo sapiens	Q969H4	Y2H Array	32296183
Intra	CYTH1	Q15438	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	CYTH1	Q15438	CCDC120	Homo sapiens	Q96HB5	Y2H Array	32296183
Intra	CYTH1	Q15438	CCDC120	Homo sapiens	Q96HB5	Y2H Prey Pooling	32296183
Intra	CYTH1	Q15438	INAVA	Homo sapiens	Q3KP66	Anti Tag CoIP	29420262

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder With Short Stature And Behavioral Abnormalities

IDDSSBA

Ankylosing Spondylitis 1

Ankylosing Spondylitis, Susceptibility To, 1

Non-Syndromic X-Linked Intellectual Disability 1

Mrx1	Mrx18
Mrx78	X-Linked Mental Retardation 1/78
X-Linked Mental Retardation 18

Psoriasis 3

PSORS3	Psoriasis Susceptibility 3
Psoriasis 3, Susceptibility To

Psoriasis 2

PSORS2	Psoriasis
Psoriasis Vulgaris	Pv
Psoriasis, Susceptibility To, Type 2

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03501	CYTH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CYTH1	RGD	RGD:620397
Felis catus	CYTH1	VGNC	VGNC:69095
Canis familiaris	CYTH1	VGNC	VGNC:49091
Macaca mulatta	CYTH1	VGNC	VGNC:71828
Bos taurus	CYTH1	VGNC	VGNC:55809
Mus musculus	CYTH1	MGD	MGI:1334257

Name
Email *

	Sorry, but the email address you supplied was invalid.