SIPA1L1 - signal induced proliferation associated 1 like 1 Gene

Homo sapiens

Also known as E6TP1; SPAR1

Gene ID: 26037 | Gene type: protein coding

About SIPA1L1

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:71,320,476-71,741,209 (from NCBI)

This gene has 18 transcripts (splice variants), 276 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 7.9), spleen (RPKM 7.4) and 25 other tissues.

Summary

Predicted to enable GTPase activator activity; actin filament binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin Cytoskeleton organization; activation of GTPase activity; and regulation of postsynapse organization. Located in actin Cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIPA1L1 Products(10)

mRNA	Protein	Name
NM_001284245.3	NP_001271174.1	signal-induced proliferation-associated 1-like protein 1 isoform 2
NM_001284246.2	NP_001271175.1	signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001284247.3	NP_001271176.1	signal-induced proliferation-associated 1-like protein 1 isoform 4
NM_001354285.2	NP_001341214.1	signal-induced proliferation-associated 1-like protein 1 isoform 1
NM_001354286.2	NP_001341215.1	signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001354287.2	NP_001341216.1	signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001354288.2	NP_001341217.1	signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001354289.2	NP_001341218.1	signal-induced proliferation-associated 1-like protein 1 isoform 5
NM_001386936.1	NP_001373865.1	signal-induced proliferation-associated 1-like protein 1 isoform 2
NM_015556.4	NP_056371.1	signal-induced proliferation-associated 1-like protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15778465	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIPA1L1 Protein Structure

Rap_GAP

SPAR_C

0
300
600
900
1200
1500
1804 a.a.

Protein Preferred Names

Protein Names

signal-induced proliferation-associated 1-like protein 1

SIPA1-like protein 1

SIPA1L1 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIPA1L1	O43166	SFN	Homo sapiens	P31947	TAP	15778465
Intra	SIPA1L1	O43166	DLG4	Homo sapiens	P78352	Y2H Pooling	21653829

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colorectal Cancer, Hereditary Nonpolyposis, Type 7

HNPCC7	Hereditary Nonpolyposis Colorectal Cancer Type 7
Hereditary Non-Polyposis Colorectal Cancer 7	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS12929	SIPA1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SIPA1L1	RGD	RGD:708497
Felis catus	SIPA1L1	VGNC	VGNC:65153
Mus musculus	SIPA1L1	MGD	MGI:2443679
Canis familiaris	SIPA1L1	VGNC	VGNC:46180
Bos taurus	SIPA1L1	VGNC	VGNC:34628
Macaca mulatta	SIPA1L1	VGNC	VGNC:77284

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