2. Gene
  3. SIPA1L1 - signal induced proliferation associated 1 like 1 Gene

SIPA1L1 - signal induced proliferation associated 1 like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as E6TP1; SPAR1

Gene ID: 26037 | Gene type: protein coding

About SIPA1L1

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:71,320,476-71,741,209 (from NCBI)

This gene has 18 transcripts (splice variants), 276 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 7.9), spleen (RPKM 7.4) and 25 other tissues.

Summary

Predicted to enable GTPase activator activity; actin filament binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin Cytoskeleton organization; activation of GTPase activity; and regulation of postsynapse organization. Located in actin Cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIPA1L1 Products(10)

mRNA Protein Name
NM_001284245.3 NP_001271174.1 signal-induced proliferation-associated 1-like protein 1 isoform 2
NM_001284246.2 NP_001271175.1 signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001284247.3 NP_001271176.1 signal-induced proliferation-associated 1-like protein 1 isoform 4
NM_001354285.2 NP_001341214.1 signal-induced proliferation-associated 1-like protein 1 isoform 1
NM_001354286.2 NP_001341215.1 signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001354287.2 NP_001341216.1 signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001354288.2 NP_001341217.1 signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001354289.2 NP_001341218.1 signal-induced proliferation-associated 1-like protein 1 isoform 5
NM_001386936.1 NP_001373865.1 signal-induced proliferation-associated 1-like protein 1 isoform 2
NM_015556.4 NP_056371.1 signal-induced proliferation-associated 1-like protein 1 isoform 1

SIPA1L1 Protein Structure

Rap_GAP

Rap_GAP: Rap/ran-GAP (628 - 816)

SPAR_C

SPAR_C: C-terminal domain of SPAR protein (1504 - 1749)

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  • 1804 a.a.
Protein Preferred Names Protein Names

signal-induced proliferation-associated 1-like protein 1

SIPA1-like protein 1

Related Diseases

Diseases Alias
Colorectal Cancer, Hereditary Nonpolyposis, Type 7

HNPCC7

Hereditary Nonpolyposis Colorectal Cancer Type 7

Hereditary Non-Polyposis Colorectal Cancer 7

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12929 SIPA1L1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SIPA1L1 RGD RGD:708497
Felis catus SIPA1L1 VGNC VGNC:65153
Mus musculus SIPA1L1 MGD MGI:2443679
Canis familiaris SIPA1L1 VGNC VGNC:46180
Bos taurus SIPA1L1 VGNC VGNC:34628
Macaca mulatta SIPA1L1 VGNC VGNC:77284