2. Gene
  3. WIPI2 - WD repeat domain, phosphoinositide interacting 2 Gene

WIPI2 - WD repeat domain, phosphoinositide interacting 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Atg21; ATG18B; CGI-50; IDDSSA; WIPI-2

Gene ID: 26100 | Gene type: protein coding

About WIPI2

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:5,190,233-5,233,855 (from NCBI)

This gene has 14 transcripts (splice variants), 223 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 20.8), brain (RPKM 12.7) and 25 other tissues.

Summary

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with Phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

WIPI2 Products(6)

mRNA Protein Name
NM_001033518.2 NP_001028690.1 WD repeat domain phosphoinositide-interacting protein 2 isoform c
NM_001033519.2 NP_001028691.1 WD repeat domain phosphoinositide-interacting protein 2 isoform d
NM_001033520.1 NP_001028692.1 WD repeat domain phosphoinositide-interacting protein 2 isoform e
NM_001278299.2 NP_001265228.1 WD repeat domain phosphoinositide-interacting protein 2 isoform f
NM_015610.4 NP_056425.1 WD repeat domain phosphoinositide-interacting protein 2 isoform a
NM_016003.4 NP_057087.2 WD repeat domain phosphoinositide-interacting protein 2 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol-3,5-bisphosphate binding IDA
IDA: Inferred from direct assay
20505359 GOA
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
20505359 GOA
enables phosphatidylinositol-5-phosphate binding IDA
IDA: Inferred from direct assay
25578879 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence Reference Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
28890335 GOA
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
20505359 GOA
NOT involved in autophagosome maturation IMP
IMP: Inferred from mutant phenotype
20505359 GOA
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
28561066 GOA
involved in protein localization to phagophore assembly site IMP
IMP: Inferred from mutant phenotype
28561066 GOA
Cellular Component GO Annotation Evidence Reference Source
NOT colocalizes with autophagosome IDA
IDA: Inferred from direct assay
20505359 GOA
located in cytosol IDA
IDA: Inferred from direct assay
20505359 GOA
colocalizes with membrane IDA
IDA: Inferred from direct assay
25578879 GOA
located in phagophore assembly site IDA
IDA: Inferred from direct assay
22456507 GOA
located in phagophore assembly site membrane IDA
IDA: Inferred from direct assay
20505359 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WIPI2 Protein Structure

WD40

WD40: WD domain, G-beta repeat (199 - 226)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

WD repeat domain phosphoinositide-interacting protein 2

WD40 repeat protein interacting with phosphoinositides 2

WIPI2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra WIPI2 Q9Y4P8 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
25416956
Intra WIPI2 Q9Y4P8 ARL6IP1 Homo sapiens Q15041
Y2H Array
25416956
Intra WIPI2 Q9Y4P8 ARL6IP1 Homo sapiens Q15041
Validated Y2H
25416956
Intra WIPI2 Q9Y4P8 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder With Short Stature And Variable Skeletal Anomalies

IDDSSA
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Neurodegeneration With Brain Iron Accumulation 5

NBIA5

Beta-Propeller Protein-Associated Neurodegeneration

Bpan

Static Encephalopathy Of Childhood With Neurodegeneration In Adulthood

Senda

Neurodegeneration With Brain Iron Accumulation Type 5

Neurodegeneration With Brain Iron Accululation 5

Static Encephalopathy Of Childhood With Neurdegeneration In Adulthood

Neurodegeneration, With Brain Iron Accululation, Type 5
Intracranial Arteriosclerosis
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15820 WIPI2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus WIPI2 VGNC VGNC:36943
Rattus norvegicus WIPI2 RGD RGD:1359154
Felis catus WIPI2 VGNC VGNC:67075
Macaca mulatta WIPI2 VGNC VGNC:79918
Mus musculus WIPI2 MGD MGI:1923831
Canis familiaris WIPI2 VGNC VGNC:48413