PYGO1 - pygopus family PHD finger 1 Gene

Homo sapiens

Gene ID: 26108 | Gene type: protein coding

About PYGO1

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:55,538,884-55,588,971 (from NCBI)

This gene has 3 transcripts (splice variants), 148 orthologues and 1 paralogue. Broad expression in thyroid (RPKM 4.1), endometrium (RPKM 3.0) and 20 other tissues.

Summary

Enables methylated histone binding activity. Predicted to be involved in kidney development and spermatid nucleus differentiation. Predicted to act upstream of or within several processes, including hematopoietic progenitor cell differentiation; protein localization to nucleus; and spermatid development. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PYGO1 Products(3)

mRNA	Protein	Name
NM_001330326.2	NP_001317255.1	pygopus homolog 1 isoform 2
NM_001367806.1	NP_001354735.1	pygopus homolog 1 isoform 2
NM_015617.3	NP_056432.1	pygopus homolog 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	18498752	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18498752	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PYGO1 Protein Structure

PHD

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

pygopus homolog 1

pygopus-like protein 1

PYGO1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PYGO1	Q9Y3Y4	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	PYGO1	Q9Y3Y4	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	PYGO1	Q9Y3Y4	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	PYGO1	Q9Y3Y4	BCL9	Homo sapiens	O00512	TAP	24981860
Intra	PYGO1	Q9Y3Y4	BCL9	Homo sapiens	O00512	X-Ray Diffraction	18498752
Intra	PYGO1	Q9Y3Y4	BCL9	Homo sapiens	O00512	GMS	18498752

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Eccrine Acrospiroma

Acrospiroma	Poroma
Eccrine Hidradenoma	Eccrine Hidradenoma Of Skin
Hidradenoma	Adenoma, Sweat Gland
Benign Neoplasm Of Sweat Gland	Eccrine Poroma

Eccrine Sweat Gland Neoplasm

Eccrine Skin Neoplasm	Eccrine Tumor
Eccrine Neoplasm	Malignant Eccrine Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11491	PYGO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PYGO1	VGNC	VGNC:33590
Canis familiaris	PYGO1	VGNC	VGNC:49878
Rattus norvegicus	PYGO1	RGD	RGD:1594620
Felis catus	PYGO1	VGNC	VGNC:64452
Mus musculus	PYGO1	MGD	MGI:1919385

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