2. Gene
  3. Aurka - aurora kinase A Gene

Aurka - aurora kinase A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Stk6; ARK-1

Gene ID: 261730 | Gene type: protein coding

About Aurka

Primary_assembly 3: 161,128,313-161,144,390 reverse strand.mRatBN7.2:CM026976.1

This gene has 5 transcripts (splice variants), 236 orthologues, 2 paralogues and is associated with 24 phenotypes. Biased expression in Adrenal (RPKM 261.), Liver (RPKM 143.3) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in protein phosphorylation and response to estradiol. Located in centrosome and spindle. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine Cancer. Orthologous to human AURKA (Aurora Kinase A). [provided by Alliance of Genome Resources, Apr 2022]

Aurka Products(1)

mRNA Protein Name
NM_153296.3 NP_695208.2 aurora kinase A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12124350 RGD
Biological Process GO Annotation Evidence Reference Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12124350 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15601761 RGD
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
12124350 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aurka Protein Structure

STKc_Aurora-A

STKc_Aurora-A: cd14116 (119 - 375)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

aurora kinase A

aurora 2

aurora-A

aurora-related kinase 1

aurora/IPL1-related kinase 1

ipl1- and aurora-related kinase 1

ratAurA

serine/threonine kinase 6

serine/threonine-protein kinase 15

serine/threonine-protein kinase 6

serine/threonine-protein kinase Ayk1

serine/threonine-protein kinase aurora-A

Related Agents

Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103645 GW779439X 99.85% Unkown
HY-112273A CD532 hydrochloride Inhibitor 99.62% Unkown
HY-157396 JAB-2485 98.11% Unkown
HY-112273 CD532 Inhibitor 98.78% Unkown
HY-137344A dAURK-4 hydrochloride Inhibitor 99.44% Unkown
HY-125956 Aurkin A Inhibitor ≥98.0% Unkown
HY-100865 BPR1K871 Inhibitor 99.12% Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-158038 AurkA allosteric-IN-1 Inhibitor / Unkown
HY-125090 PHA-680626 / Unkown
HY-137344 dAURK-4 Inhibitor / Unkown
HY-147703 Aurora kinase inhibitor-9 Inhibitor / Unkown
HY-155464 VEGFR-2/AURKA-IN-1 Chemical / Unkown
HY-161407 AURKA-IN-1 Inhibitor / Unkown
HY-162469 6K465 Inhibitor / Unkown
HY-162837 AURKA against 1 Inhibitor / Unkown
HY-168540 PROTAC MPS1 degrader 1 Degrader / Unkown
HY-168543 PROTAC MPS1 degrader 2 Degrader / Unkown
HY-RS01266 AURKA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01267 Aurka Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01268 Aurka Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aurka NCBI NCBI:6790