2. Gene
  3. SPAG8 - sperm associated antigen 8 Gene

SPAG8 - sperm associated antigen 8 Gene

  • Gene
  • Protein
Homo sapiens (human)

Also known as SMP1; BS-84; CT142; HSD-1; SPAG3; CILD28; hSMP-1

Gene ID: 26206 | Gene type: protein coding

About SPAG8

Summary

The correlation of anti-sperm Antibodies with cases of unexplained infertility implicates a role for these Antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating Antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq, Jul 2012]

SPAG8 Products(1)

mRNA Protein Name
XM_054362718.1 XP_054218693.1 sperm-associated antigen 8 isoform X3
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24722188 GOA
Cellular Component GO Annotation Evidence Reference Source
located in axonemal microtubule IDA
IDA: Inferred from direct assay
36191189 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sperm-associated antigen 8

sperm membrane protein 1

sperm membrane protein BS-84

testicular tissue protein Li 177

SPAG8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SPAG8 Q99932 SNRPC Homo sapiens Q5TAL4
Y2H Array
25416956
Intra
SPAG8 Q99932 KLHL32 Homo sapiens Q5THT1
Y2H Array
25416956
Intra
SPAG8 Q99932 CSTF2 Homo sapiens P33240
Validated Y2H
25416956
Intra
SPAG8 Q99932 DTX2 Homo sapiens Q86UW9
Y2H Array
25416956
Intra
SPAG8 Q99932 DTX2 Homo sapiens Q86UW9
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction