CSTF2 - cleavage stimulation factor subunit 2 Gene

Homo sapiens

Also known as CstF-64

Gene ID: 1478 | Gene type: protein coding

About CSTF2

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,820,391-100,841,520 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 6.8), testis (RPKM 6.5) and 24 other tissues.

Summary

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]

CSTF2 Products(3)

mRNA	Protein	Name
NM_001306206.2	NP_001293135.1	cleavage stimulation factor subunit 2 isoform 1
NM_001306209.2	NP_001293138.1	cleavage stimulation factor subunit 2 isoform 3
NM_001325.3	NP_001316.1	cleavage stimulation factor subunit 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	1741396	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10477523	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	32816001	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cleavage body	IDA IDA: Inferred from direct assay	11598190	GOA
part of mRNA cleavage and polyadenylation specificity factor complex	IDA IDA: Inferred from direct assay	18305108	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	32816001	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSTF2 Protein Structure

RRM_1

CSTF2_hinge

CSTF_C

0
100
200
300
400
500
577 a.a.

Protein Preferred Names

Protein Names

cleavage stimulation factor subunit 2

CF-1 64 kDa subunit

CSTF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CSTF2	P33240	CTBP2	Homo sapiens	P56545-3	Validated Y2H	32296183
Intra	CSTF2	P33240	CTBP2	Homo sapiens	P56545-3	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	CTBP2	Homo sapiens	P56545-3	Y2H Array	32296183
Intra	CSTF2	P33240	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	CSTF2	P33240	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	CSTF2	P33240	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	CSTF2	P33240	METTL15	Homo sapiens	A6NJ78-4	Y2H Array	32296183
Intra	CSTF2	P33240	METTL15	Homo sapiens	A6NJ78-4	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	CPSF2	Homo sapiens	Q9P2I0	Anti Tag CoIP	18688255
Intra	CSTF2	P33240	PRDM6	Homo sapiens	Q9NQX0	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	PRDM6	Homo sapiens	Q9NQX0	Validated Y2H	32296183
Intra	CSTF2	P33240	PRDM6	Homo sapiens	Q9NQX0	Y2H Array	32296183
Intra	CSTF2	P33240	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	CSTF2	P33240	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	CSTF2	P33240	SPAG8	Homo sapiens	Q99932-2	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	CSTF2	P33240	SPAG8	Homo sapiens	Q99932-2	Y2H Array	32296183
Intra	CSTF2	P33240	USP54	Homo sapiens	Q70EL1-9	Validated Y2H	32296183
Intra	CSTF2	P33240	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	CSTF2	P33240	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	CSTF2	P33240	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Array	32296183
Intra	CSTF2	P33240	TLE3	Homo sapiens	Q04726-4	Y2H Array	32296183
Intra	CSTF2	P33240	TLE3	Homo sapiens	Q04726-4	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	TLE3	Homo sapiens	Q04726-4	Validated Y2H	32296183
Intra	CSTF2	P33240	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	CSTF2	P33240	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	CSTF2	P33240	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	UFSP1	Homo sapiens	Q6NVU6	Y2H Array	32296183
Intra	CSTF2	P33240	UFSP1	Homo sapiens	Q6NVU6	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	UFSP1	Homo sapiens	Q6NVU6	Validated Y2H	32296183
Intra	CSTF2	P33240	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	ANKRD10	Homo sapiens	Q9NXR5-2	Validated Y2H	32296183
Intra	CSTF2	P33240	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Array	32296183
Intra	CSTF2	P33240	FAM168B	Homo sapiens	A1KXE4-2	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	FAM168B	Homo sapiens	A1KXE4-2	Y2H Array	32296183
Intra	CSTF2	P33240	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Array	32296183
Intra	CSTF2	P33240	ABHD11	Homo sapiens	Q8NFV4-4	Validated Y2H	32296183
Intra	CSTF2	P33240	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32296183
Intra	CSTF2	P33240	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
Intra	CSTF2	P33240	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	ATP23	Homo sapiens	Q9Y6H3	Validated Y2H	32296183
Intra	CSTF2	P33240	ATP23	Homo sapiens	Q9Y6H3	Y2H Array	32296183
Intra	CSTF2	P33240	ATP23	Homo sapiens	Q9Y6H3	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	STH	Homo sapiens	Q8IWL8	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	STH	Homo sapiens	Q8IWL8	Validated Y2H	32296183
Intra	CSTF2	P33240	STH	Homo sapiens	Q8IWL8	Y2H Array	32296183
Intra	CSTF2	P33240	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Array	32296183
Intra	CSTF2	P33240	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	TFG	Homo sapiens	Q92734	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	TFG	Homo sapiens	Q92734	Validated Y2H	25416956
Intra	CSTF2	P33240	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	CSTF2	P33240	TFG	Homo sapiens	Q92734	Y2H Array	32296183
Intra	CSTF2	P33240	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	CSTF2	P33240	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	CSTF2	P33240	PARN	Homo sapiens	O95453	Anti Bait CoIP	20379136
Intra	CSTF2	P33240	CEACAM6	Homo sapiens	P40199	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	CEACAM6	Homo sapiens	P40199	Validated Y2H	32296183
Intra	CSTF2	P33240	CEACAM6	Homo sapiens	P40199	Y2H Array	32296183
Intra	CSTF2	P33240	BARD1	Homo sapiens	Q99728	Anti Bait CoIP	20379136
Intra	CSTF2	P33240	BARD1	Homo sapiens	Q99728	Anti Bait CoIP	10477523
Intra	CSTF2	P33240	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	CSTF2	P33240	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	CSTF2	P33240	HGS	Homo sapiens	O14964	Y2H Array	25416956
Intra	CSTF2	P33240	HGS	Homo sapiens	O14964	Y2H Array	32296183
Intra	CSTF2	P33240	HGS	Homo sapiens	O14964	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	CSTF2	P33240	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	16189514
Intra	CSTF2	P33240	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	25416956
Intra	CSTF2	P33240	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	CSTF2	P33240	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	CSTF2	P33240	CNOT2	Homo sapiens	Q9NZN8	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	CNOT2	Homo sapiens	Q9NZN8	Validated Y2H	32296183
Intra	CSTF2	P33240	CNOT2	Homo sapiens	Q9NZN8	Y2H Array	32296183
Intra	CSTF2	P33240	HDHD3	Homo sapiens	Q9BSH5	Validated Y2H	32296183
Intra	CSTF2	P33240	HDHD3	Homo sapiens	Q9BSH5	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	HDHD3	Homo sapiens	Q9BSH5	Y2H Array	32296183
Intra	CSTF2	P33240	RFX6	Homo sapiens	Q8HWS3	Validated Y2H	32296183
Intra	CSTF2	P33240	RFX6	Homo sapiens	Q8HWS3	Y2H Array	32296183
Intra	CSTF2	P33240	RFX6	Homo sapiens	Q8HWS3	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	METTL27	Homo sapiens	Q8N6F8	Y2H Array	32296183
Intra	CSTF2	P33240	METTL27	Homo sapiens	Q8N6F8	Validated Y2H	32296183
Intra	CSTF2	P33240	METTL27	Homo sapiens	Q8N6F8	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	ZNF341	Homo sapiens	Q9BYN7	Validated Y2H	25416956
Intra	CSTF2	P33240	ZNF341	Homo sapiens	Q9BYN7	Y2H Prey Pooling	25416956
Intra	CSTF2	P33240	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	CSTF2	P33240	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	CSTF2	P33240	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	CSTF2	P33240	SPAG8	Homo sapiens	Q99932	Y2H Prey Pooling	25416956
Intra	CSTF2	P33240	SPAG8	Homo sapiens	Q99932	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03274	CSTF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03275	CSTF2T Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CSTF2	VGNC	VGNC:39683
Macaca mulatta	CSTF2	VGNC	VGNC:71536
Mus musculus	CSTF2	MGD	MGI:1343054
Rattus norvegicus	CSTF2	RGD	RGD:1596566
Bos taurus	CSTF2	VGNC	VGNC:27781
Felis catus	CSTF2	VGNC	VGNC:61240

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