FBXW8 - F-box and WD repeat domain containing 8 Gene

Homo sapiens

Also known as FBW6; FBW8; FBX29; FBXW6; FBXO29

Gene ID: 26259 | Gene type: protein coding

About FBXW8

Cytogenetic location: 12q24.22 Genomic coordinates (GRCh38): 12:116,910,950-117,031,148 (from NCBI)

This gene has 4 transcripts (splice variants), 191 orthologues and 14 paralogues. Ubiquitous expression in thyroid (RPKM 4.3), ovary (RPKM 2.4) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

FBXW8 Products(2)

mRNA	Protein	Name
NM_012174.2	NP_036306.1	F-box/WD repeat-containing protein 8 isoform 2
NM_153348.3	NP_699179.2	F-box/WD repeat-containing protein 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15070733	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	24362026	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IGI IGI: Inferred from genetic interaction	21572988	GOA
involved in cell population proliferation	IDA IDA: Inferred from direct assay	24362026	GOA
involved in positive regulation of dendrite morphogenesis	IDA IDA: Inferred from direct assay	21572988	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	18498745	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of 3M complex	IDA IDA: Inferred from direct assay	24793695	GOA
part of Cul7-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	18498745	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	21572988	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21572988	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXW8 Protein Structure

F-box-like

WD40

0
100
200
300
400
500
598 a.a.

Protein Preferred Names

Protein Names

F-box/WD repeat-containing protein 8

F-box and WD-40 domain protein 8

FBXW8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FBXW8	Q8N3Y1	MYC	Homo sapiens	P01106	Anti Tag CoIP	17314511

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Three M Syndrome 1

3-M Syndrome	Yakut Short Stature Syndrome
3m Syndrome	Le Merrer Syndrome
Dolichospondylic Dysplasia	Gloomy Face Syndrome
Three M Syndrome	3M1
3m Syndrome 1	Miller-Mckusick-Malvaux Syndrome
3-Msbn	Three-M Slender-Boned Nanism
Miller-Mckusick-Malvaux-Syndrome	3-M Syndrome 1
3m Syndrome-1	3m Syndrome, Type 1
Dwarfism	Dwarfism Tall Vertebrae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04819	FBXW8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FBXW8	VGNC	VGNC:62205
Rattus norvegicus	FBXW8	RGD	RGD:1306032
Mus musculus	FBXW8	MGD	MGI:1923041
Canis familiaris	FBXW8	VGNC	VGNC:40798
Macaca mulatta	FBXW8	VGNC	VGNC:72497
Bos taurus	FBXW8	VGNC	VGNC:58599

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